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  4. Recombinant Mouse Adrenocortical dysplasia protein (Acd)

Recombinant Mouse Adrenocortical dysplasia protein (Acd)

  • 货号：
    CSB-YP682726MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP682726MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP682726MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP682726MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP682726MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    AcdAdrenocortical dysplasia protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-416
  • 氨基酸序列
    MSDSGLLALQ PWIRELILGS ETLSSPRTGQ LLKVLQDSET PGPSSAPDTP DTGAVLLVSD GTHSVRCVVT RNAIDTSDWE EKELGFRGTE GRLLLLQACG LRVQVAQDHA PAEFYLQVDR FNLLPTEQPR IQVTGCNQDS DVQRKLNECL EDHLSESASS SAGLTLSQLL DEVREDQDHR GALVCLAKSC LVLKGPCTTT PLTDWITSGS QALGKAVFTV SGSLLHIPEG EEQILSSTGS SQKARGTSAS PSHMPLEESG ASVSLLSALA TSDPGQMDSS QSPPAVGSTS PRAQAPTSPP CNSTPSSLLL NCSPSLSPLH PAPRSHQSCE TRAQAPKLEF QCSFKKRQLL PRTSAQELCS VWEPPERHRD TSAFQYKYET PSASLHTQVQ TARLSPQLVA WALNIVMESE SELTQV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
  • 基因功能参考文献：
    1. Analyses demonstrate that the majority of differentially expressed genes in acd mutant embryos are due to p53-dependent mechanisms and reflect the observed phenotypic differences between acd mutant and double mutant embryos. PMID: 30189268
    2. Mouse hematopoietic stem cells are acutely sensitive to inactivation of the shelterin gene Acd. PMID: 24316971
    3. telomeric regulator is required for proper urogenital ridge differentiation, axial skeleton specification and limb patterning in mice. PMID: 15537664
    4. Tumors from Acd(acd/acd) p53(+/-) mice show a striking switch from the classic spectrum of p53(-/-) mice toward carcinomas. PMID: 19477426
  • 相关疾病：
    Defects in Acd are the cause of adrenocortical dysplasia (ACD). ACD is a spontaneous autosomal recessive mouse mutant resulting from spontaneous splicing mutation of acd. ACD mice are characterized by developmental defects in organs derived from the urogenital ridge, reduced survival, poor growth, skin hyperpigmentation and adrenal insufficiency. Forty percent of the mutants died within 24 hours. Analysis of E14.5 to E17.5 embryos revealed reduced formation of caudal structure as well as limb defects.
  • 亚细胞定位：
    Nucleus. Chromosome, telomere.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    KEGG: mmu:497652

    STRING: 10090.ENSMUSP00000048180

    UniGene: Mm.12964