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  4. Recombinant Mouse Akirin-1 (Akirin1)

Recombinant Mouse Akirin-1 (Akirin1)

  • 货号：
    CSB-YP859975MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP859975MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP859975MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP859975MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP859975MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Akirin1
  • Uniprot No.：
  • 别名：
    Akirin1; Mighty; MNCb-2831Akirin-1; Mighty protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-191
  • 氨基酸序列
    MACGATLKRP MEFEAALLSP GSPKRRRCAP LPGPTPGLRP PDAEPPPLQM QTPPASLQQP APPGSERRLP TPEQIFQNIK QEYNRYQRWR HLEVVLSQSE ACTSETQPSS SALTAPGSPG AFWMKKDQPT FTLRQVGIIC ERLLKDYEDK VREEYEQILS TKLAEQYESF VKFTHDQIMR RYGTRPTSYV S
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as signal transducer for MSTN during skeletal muscle regeneration and myogenesis. May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway.
  • 基因功能参考文献：
    1. that mouse Akhirin plays a crucial role in mouse spinal cord formation by regulating the ependymal niche in the central canal PMID: 25331329
    2. glucocorticoids stimulate myostatin which inhibits Akirin1 expression and the reparative functions of satellite cells PMID: 23516508
    3. Mighty is a critical promyogenic factor which plays a key role in the signalling pathway downstream of Myostatin. PMID: 18255059
    4. myostatin regulates key steps of muscle regeneration including chemotaxis of inflammatory cells, SC activation and migration through akirin1. PMID: 19406121
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Akirin family
  • 组织特异性：
    Expressed in macrophages and satellite cells.
  • 数据库链接：

    KEGG: mmu:68050

    STRING: 10090.ENSMUSP00000099696

    UniGene: Mm.27903