Recombinant Mouse Alpha-defensin 1 (Defa1)
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中文名称:Recombinant Mouse Alpha-defensin 1(Defa1)
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货号:CSB-YP006652MO
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规格:¥2208
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图片:
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其他:
产品详情
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纯度:Greater than 90% as determined by SDS-PAGE.
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基因名:Defa1
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Uniprot No.:
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别名:Defa1; Defcr; Defcr1Alpha-defensin 1; Cryptdin-1; Defensin-related cryptdin peptide
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种属:Mus musculus (Mouse)
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蛋白长度:Full Length of Mature Protein
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来源:Yeast
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分子量:31.1kDa
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表达区域:59-93aa
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氨基酸序列LRDLVCYCRSRGCKGRERMNGTCRKGHLLYTLCCR
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request. -
蛋白标签:N-terminal GST-tagged
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产品提供形式:Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
缓冲液:Tris-based buffer,50% glycerol
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储存条件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保质期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事项:Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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产品描述:
The production of this Recombinant Mouse Defa1 protein required the insertion of a DNA fragment (Defa1, 59-93aa) into a plasmid vector and the transferral of this vector into Yeast cells (the step of transformation). The cells were then cultured and induced to express the Defa1 protein. This recombinant protein was fused with N-terminal GST tag. Its purity is 90%+ determined by SDS-PAGE.
Defa1 (also called Defcr or Defcr1) is a gene providing an instruction of making a protein named alpha-defensin 1 (Defa1) in mus musculus (mouse). Defa1 protein is also known as cryptdin-1 or defensin-related cryptdin peptide and belongs to alpha-defensin (α-defensin) family. Mammalian α-defensins are cationic antimicrobial peptides (AMPs) with microbicidal activities against many species of bacteria (such as gram-negative and gram-positive bacterium) and fungi, antiviral functions, and diverse immunomodulatory effects (such as innate immune response in mucosa).
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Datasheet & COA:Please contact us to get it.
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靶点详情
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功能:Probably contributes to the antimicrobial barrier function of the small bowel mucosa. Has antibacterial activity against attenuated mutants of S.typhimurium.
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基因功能参考文献:
- Mouse adenovirus 2 infection was enhanced by enteric alpha-defensins. PMID: 28622386
- Decreased alpha-defensin is associated with intestinal inflammation in a model of inflammatory bowel disease. PMID: 20222124
- cryptdin-1 and cryptdin-4 exhibit circadian oscillation PMID: 16129697
- the Arg5-Glu13 salt bridge in alpha-defensin is conserved for defensin in vivo stability PMID: 16246847
- MMP-7 activates mouse paneth cell pro-alpha-defensins PMID: 16822871
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亚细胞定位:Secreted.
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蛋白家族:Alpha-defensin family
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组织特异性:Paneth cells of the small bowel.
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数据库链接:
KEGG: mmu:13216
UniGene: Mm.425522
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