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  4. Recombinant Mouse Amyloid beta A4 precursor protein-binding family A member 3 (Apba3)

Recombinant Mouse Amyloid beta A4 precursor protein-binding family A member 3 (Apba3)

  • 货号：
    CSB-YP001889MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP001889MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP001889MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP001889MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP001889MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Apba3
  • Uniprot No.：
  • 别名：
    Apba3; Mint3Amyloid-beta A4 precursor protein-binding family A member 3; Adapter protein X11gamma; Neuron-specific X11L2 protein; Neuronal Munc18-1-interacting protein 3; Mint-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-571
  • 氨基酸序列
    MEFLPGPQHP PGPPTMDLEE PKGPEVPSEN HPSNTQSALG PGGPVTLSEM ELDTSSVQEL VQQLEALPSD LGGPFPDGAP CPLHIATGQG LATQENPDAG GLLSAEAGGD DLLGLLRDEA SSPAQSVPQD PAQTAPRLLQ PPEDPDGDPG WMEGASAEPA DSRSSSSSPE PWLETAPLVT QQEPPVGTQS RETLASCPAV TEVPGPCGPE ELMDGVIFGA KYLGSTQLLS ERSPAPSTRM GQAQEAMDRV KAPEGETQPM VEVDIFISTK RVKVLAADSQ DALMDHALQT ISYIADIGPV LVLMARRRLA RRTTPQDRQR RLYKMLCHVF HSEDAQLIAQ AIGQAFSIAY SQFLQENRID PSQVGTQPST AASHPHNGDL DHFCNSQNCR EVCIQKRPGE GLGVALVESG WGSLLPTAVI ANLLHGGPAE RCGALSIGDR VTAINGTSLV GLSLAACQAA VREVRRLSSV TLSIIHCPPV TTAVIRRPHV REQLGFCVED GIICSLLRGG AAERGGVRVG HRIIEVNGQS VVAMPHARII QLLTETREIH IKTMPAATYR LLTGQEQPVY L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.
  • 基因功能参考文献：
    1. APBA3-deficient mice show reduced metastasis, with no apparent effect on primary tumor growth. APBA3 deficiency in inflammatory monocytes hampers glycolysis-dependent chemotaxis of cells toward metastatic sites. PMID: 28507122
    2. we have identified Mint3 as a physiological positive regulator of TLR3/4 and RIG-I-induced IFN-beta production and have outlined a feedback mechanism for the control of antiviral immune responses. PMID: 27698125
    3. Mint3 depletion attenuated metastasis to the lungs in breast cancer model mice. PMID: 28634075
    4. Deletion of the Mint3/Apba3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccharide-induced septic shock. PMID: 21778228
    5. Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV PMID: 14990567
    6. Mints are important regulators of presynaptic neurotransmitter release that are essential for mouse survival. PMID: 17167098
    7. Binding of Munc18-1 to closed, target-SNARE syntaxin 1 stimulates vesicle docking and regulates the consecutive priming step during exocytosis of secretory or synaptic vesicles. PMID: 17687045
    8. X11L2 functions in the nucleus by a mechanism distinct from conventional transactivators PMID: 18201694

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  • 亚细胞定位：
    Cytoplasm, perinuclear region.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    KEGG: mmu:57267

    STRING: 10090.ENSMUSP00000050995

    UniGene: Mm.293931