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  4. Recombinant Mouse Amyloid beta A4 precursor protein-binding family B member 1 (Apbb1)

Recombinant Mouse Amyloid beta A4 precursor protein-binding family B member 1 (Apbb1)

  • 中文名称：
    Recombinant Mouse Amyloid beta A4 precursor protein-binding family B member 1(Apbb1),Yeast
  • 货号：
    CSB-YP865578MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Amyloid beta A4 precursor protein-binding family B member 1(Apbb1),Yeast
  • 货号：
    CSB-EP865578MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Amyloid beta A4 precursor protein-binding family B member 1(Apbb1),Yeast
  • 货号：
    CSB-EP865578MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Amyloid beta A4 precursor protein-binding family B member 1(Apbb1),Yeast
  • 货号：
    CSB-BP865578MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Amyloid beta A4 precursor protein-binding family B member 1(Apbb1),Yeast
  • 货号：
    CSB-MP865578MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Apbb1
  • Uniprot No.：
  • 别名：
    Apbb1; Fe65Amyloid-beta A4 precursor protein-binding family B member 1; Protein Fe65
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-710
  • 氨基酸序列
    MSVPSSLSQS AINANSHGGP ALSFPLPLHA AHNQLLNAKL QATAVVPKDL RSAMGEGSVP EPGPANAKWL KEGQNQLRRA ATAHRDQNRN VTLTLAEEAS QEAETAPLGP KGLMHLYSEL ELSAHNAANR GLHGSALIIN TQEQGPDEGE EKAAGEAEED DEDEEEEEEE EDLSSPPGLP EPLENVEVPS GPQALTDGPR EHSKSASLLF GMRNSAASDE DSSWATLSQG SPSYGSPEDT DSFWNPNAFE TDSDLPAGWM RVQDTSGTYY WHIPTGTTQW EPPGRASPSQ GSSPQEESQL TWTGFAHQEG FEEGEFWKDE PSEEAPMELG LKDPEEATLS FPAQSLSPEP VPQEEEKLSQ RNANPGIKCF AVRSLGWVEM TEEELAPGRS SVAVNNCIRQ LSYHKNNLHD PMAGGWGEGK DLLLQLEDET LKLVEPQNQT LLHAQPIVSI RVWGVGRDSG SNRDFAYVAR DKLTQMLKCH VFRCEAPAKN IATSLHEICS KIMSERRNAR CLVNGLSLDH SKLVDVPFQV EFPAPKNELV QKFQVYYLGN VPVAKPVGVD VINGALESVL SSSSREQWTP SHVSVAPATL TILHQQTEAV LGECRVRFLS FLAVGRDVHT FAFIMAAGPA SFCCHMFWCE PNAASLSEAV QAACMLRYQK CLDARSQTST SCLPAPPAES VARRVGWTVR RGVQSLWGSL KPKRLGSQTP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning. Plays a role in the maintenance of lens transparency. May play a role in muscle cell strength.
  • 基因功能参考文献：
    1. These data demonstrate a role for FE65 proteins at central and peripheral synapses. PMID: 27734846
    2. Jagged1 is a novel binding partner of Fe65, and Fe65 may act as a novel effector of Jagged1 signaling. PMID: 26276215
    3. results provide strong evidence that Fe65 plays a role in DNA damage response and cell viability by epigenomic regulation of specific transcriptional programs activated upon genotoxic stress. PMID: 26255939
    4. Findings show that amyloid precursor protein-binding proteins FE65 and FE65L1 are essential for the maintenance of lens transparency. PMID: 25757569
    5. our data suggest that FE65 serves as a link between VLDLR and APP PMID: 22429478
    6. FE65 small interfering RNA does not influence Rac1 expression or its activity, although it acts as an adaptor protein with several protein-interaction domains. PMID: 21878794
    7. Fe65 carries out different functions depending on its location in the regulation of Notch1 signaling. PMID: 22199353
    8. a unique role for the 97 kDa isoform in controlling GnRH-1 neurogenesis that is not redundant with the 60 kDa isoform of FE65. PMID: 21228158
    9. Results confirm that megalin interacts with APP and FE65, suggesting that these three proteins form a tripartite complex. PMID: 20637285
    10. Data show that the carboxyl-terminal half of FE65, which contains the PI2 domain, failed to stabilize p53, suggesting that the amino-terminal half of the protein plays an important role in the stabilization of p53 in osmotically stressed cells. PMID: 20036665
    11. cell cycle progression by down-regulating thymidylate synthase expression PMID: 12089154
    12. The areas of highest Fe65 expression included the hippocampus, in which the earliest abnormalities of Alzheimer's disease are detectable. Fe65 also occurred in the cerebellum, thalamus and some brain stem nuclei. Fe65 occurred in hippocampal astrocytes. PMID: 12435432
    13. These studies suggest an important and novel function of FE65 in learning and memory. PMID: 14689444
    14. p65FE65 may be an intracellular mediator in a signaling cascade regulating alpha-secretion of APP PMID: 15647266
    15. Targeted deletion of two members of the FE65 family of adaptor proteins, FE65 and FE65L1, results in cortical dysplasia and suggests that FE65 proteins are involved in basement membrane assembly. PMID: 16407979
    16. phosphorylation of APP(amyloid beta-protein precursor) modulates FE65-dependent gene transactivation through the regulation of FE65 intracellular localization. PMID: 16716194
    17. Fe65 plays an essential role in the response of the cells to DNA damage PMID: 17121854
    18. The present study shows that 17beta-estradiol inhibits the transcriptional and apoptotic activities of the APPct complex by a process involving the interaction of estrogen receptor alpha (ERalpha) with Fe65. PMID: 17130235
    19. Notch1 intracellular domain plays the role of a negative regulator in AICD signaling via the disruption of the AICD-Fe65-Tip60 trimeric complex. PMID: 17368826
    20. a complex including APP, FE65 and an additional protein is involved in neurite outgrowth at early stages of neuronal development PMID: 17383198
    21. Fe65 regulation of APP proteolysis may be integrally associated with its nuclear signaling function, as all antecedent proteolytic steps prior to release of Fe65 from the membrane are fostered by the APP-Fe65 interaction PMID: 17855370
    22. a TAG1-APP signalling pathway negatively modulates neurogenesis through Fe65 PMID: 18278038
    23. observed similar up-regulation of Nme1 and Nme2 genes, both at the transcript and the protein levels, in the brain of Fe65 knock-out mice, thus highlighting the occurrence of evolutionary conserved mechanisms of Nme expression in nematodes and mammals PMID: 18401706
    24. APP-regulated FE65 plays an important role in the early stress response of cells and that FE65 deregulated from APP induces apoptosis. PMID: 18468999
    25. Fe65 and its interaction with APP play an important role in the response to DNA damage by assisting the recruitment of Tip60-TRRAP to DNA damage sites. PMID: 19282473
    26. These results demonstrate novel roles of FE65 in synaptic plasticity, acquisition, and retention for certain forms of memory formation. PMID: 19713352
    27. the translocation of FE65 to the nuclear matrix, along with the formation of nuclear patches, is required for the stabilization of p53 by its suppression of the proteasome degradation pathway. PMID: 19796171

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  • 亚细胞定位：
    Cell membrane. Cytoplasm. Nucleus. Cell projection, growth cone. Nucleus speckle.
  • 组织特异性：
    Expressed in the brain, retinal lens and muscle cells (at protein level).
  • 数据库链接：

    KEGG: mmu:11785

    STRING: 10090.ENSMUSP00000079932

    UniGene: Mm.38469