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  4. Recombinant Mouse Angiomotin-like protein 2 (Amotl2)

Recombinant Mouse Angiomotin-like protein 2 (Amotl2)

  • 货号：
    CSB-YP809099MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP809099MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP809099MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP809099MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP809099MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Amotl2
  • Uniprot No.：
  • 别名：
    Amotl2Angiomotin-like protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-772
  • 氨基酸序列
    MRTLEDSSGT VLHRLIQEQL RYGNLTETRT LLAIQQQALR GGAGAGGTGS PQASLEIGAP EDSQVLQQAT RQEPQGQEHQ GGETHLAENR LYRLCPQPSK GEELPTYEEA KAHSQYYAAQ QAGSRPHVGD RDPRGGVSGG GRRQDEALRE LRHGHVRSLS ERLLQLSLER NGARVPSHMS SSHSFPQLAR SQQGPQPRGP PAEGPEPRGP PPQYPHAVMA QETAAVTDPR YRPRSSPHFQ HAEVRILQAQ VPPVFLQQQQ YQYLPQPQEH SPPLHPAALG HGPPSSFGPP AVEGPPSAQA TLGSAHLAQM ETVLRENARL QRDNERLQRE LESTSEKAGR IEKLENEIQR LSEAHESLMR TSSKREALEK TMRNKMDGEM RRLQDFNRDL RERLESANRH LASKTQEAQA GSQDMVAKLL AQSYEQQQEQ EKLEREMALL RGAIEDQRRH AELLEQALGN AQSRAARAEE ELRKKQAYVE KVERLQQALG QLQAACEKRE QLELRLRTRL EQELKALRAQ QRQTGTLAGG GGSHGGSAEL SALRLSEQLR EKEEQILALE ADMTKWEQKY LEERAMRQFA MDAAATAAAQ RDTTLIRHSP QPSPSSSFNE GLLPGNHRHQ EMESRLKVLH AQILEKDAVI KVLQQRSRKD PGKATQGTLR PAKSVPSIFA AAVGTQGWQG LVSSERQTDA RPAGDRVPAE EPPATAPLPA HTKHGSRDGS TQTDGPADNT SACLASEPDG LLGCNSSQRT PSLDSIAATR VQDLSDMVEI LI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
  • 基因功能参考文献：
    1. AmotL2 disrupts apical-basal cell polarity and promotes tumor invasion. PMID: 25080976
    2. Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells PMID: 21937427
  • 亚细胞定位：
    Recycling endosome.
  • 蛋白家族：
    Angiomotin family
  • 数据库链接：

    KEGG: mmu:56332

    STRING: 10090.ENSMUSP00000035121

    UniGene: Mm.21145