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  4. Recombinant Mouse Annexin A2 (Anxa2)

Recombinant Mouse Annexin A2 (Anxa2)

  • 货号：
    CSB-YP001840MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP001840MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP001840MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Anxa2; Anx2; Cal1hAnnexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-339
  • 氨基酸序列
    STVHEILCK LSLEGDHSTP PSAYGSVKPY TNFDAERDAL NIETAVKTKG VDEVTIVNIL TNRSNVQRQD IAFAYQRRTK KELPSALKSA LSGHLETVIL GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDII SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDARELYD AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM LESIKKEVKG DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.
  • 基因功能参考文献：
    1. PTGS2 deletion changes the natural distribution of ANXA2 in monocytes/macrophages, increasing TF expression and activity predisposing to venous thrombosis. PMID: 28536720
    2. Our data indicate that hepatic overexpression of ANX1 and ANX2 inhibits APAP-induced expansion of liver injury PMID: 27451051
    3. This study indicated that AnxA2 played complex roles in traversal of C. neoformans across host brain microvascular endothelial cells. PMID: 28130864
    4. contributes to pulmonary microvascular integrity by enabling vascular endothelial cadherin-related phosphatase activity, thereby preventing vascular leak during alveolar hypoxia PMID: 28694388
    5. our studies show that this G-motif represents a novel and essential determinant for axonal localization of the Anxa2 mRNA mediated by the SMN complex. PMID: 28258160
    6. Despite comparable fungal burden, Anxa2(-/-) mice died more rapidly than wild-type mice when infected with Cryptococcus neoformans, and Anxa2(-/-) mice exhibited enhanced inflammatory responses PMID: 27371724
    7. annexin A2 contributes to lung injury and fibrotic disease by mediating the fibrogenic actions of FXa. PMID: 28283478
    8. Our findings reveal a previously undemonstrated function for AnxA2 in inflammatory response in polymicrobial sepsis models PMID: 27389701
    9. Podxl-overexpression in neural stem/progenitor cells leads to an up-regulation of Annexin A2. PMID: 27470587
    10. The tick protein sialostatin L2 binds to annexin A2 and inhibits NLRC4-mediated inflammasome activation. PMID: 27045038
    11. Data show that annexin A2 (AnxA2) directly exerted negative regulation of inflammatory responses through Toll-like receptor 4 (TLR4)-initiated TRAM protein-TRIF protein pathway occurring on endosomes. PMID: 26527544
    12. the role of Axna2 is instructive for understanding the development of RA, suppress the effect of Axna2 might provide a new potential measure for treatment of RA. PMID: 26963384
    13. Taken together, these findings indicate for the first time that AnxA2 phosphorylation and actin remodeling evoked by oxidative stress depend on the sphingolipid pathway, via MMP2 and p38MAPK. PMID: 25574848
    14. Data indicate that annexin A2 (AnxA2) regulates the secretion of semaphorin 3D (Sema3D) from pancreatic ductal adenocarcinoma (PDA) cells. PMID: 26243191
    15. results suggest that legumain expression and activation and cleavage of annexin A2 are regulated by DJ-1 through p53 PMID: 26462467
    16. AnxA2 regulates autophagy, thereby contributing to host immunity against bacteria through the Akt1-mTOR-ULK1/2 signaling pathway PMID: 26371245
    17. These data suggest that AnxA2 and AnxA5 can influence bone formation via regulation of osteoprogenitor proliferation, differentiation, and responsiveness to cytokines in addition to their well-studied function in matrix vesicles PMID: 25222280
    18. The tumor microenvironment interaction between ANXA2-CXCL12 is critical for metastatic phenotypes and may impact chemotherapeutic potential. PMID: 25139998
    19. Our results support a model whereby AnxA2 limits the availability of TRPA1 channels to regulate nociceptive signaling in vertebrates. PMID: 25355205
    20. Absence of ANXA2 leads to retention of COL6 in a late-Golgi, VAMP2-positive compartment. PMID: 24357721
    21. data revealed a plausible new role of AnxA2 in the reduction of PCSK9 protein levels via a translational mechanism. PMID: 24808179
    22. results suggest an involvement of AnxA2 in potentiating glutamate-induced cell death processes PMID: 24742684
    23. Plasminogen stimulates autocrine cytokine production in human airway smooth muscle cells in a manner mediated by plasmin and annexin A2. PMID: 23721211
    24. an annexin A2 niche in cell fate regulation PMID: 23148505
    25. AnxA2 acts as an endogenous regulator of PCSK9-induced LDLR degradation PMID: 22848640
    26. Tissue plasminogen activator activates the NF-kappaB pathway in macrophages through a signaling pathway involving annexin A2/CD11b-mediated integrin-linked kinase. PMID: 22677557
    27. The results of the present study demonstrate the relevance of ANXII in vivo and suggest that methionine-induced hyperhomocysteinemia may reverse hyperfibrinolysis in APL. PMID: 22517898
    28. results indicate a functional role of annexin A2 binding to endosomal membranes following organelle destabilization PMID: 22453828
    29. ANXA2 redox regulatory function plays an important role protecting cells from oxidative stress, particularly during tumorigenesis. PMID: 22185818
    30. Data demonstrate the presence of a binding site on the 3'-untranslated region of NR1 mRNA for AnxA2 and show the regulation of NR1 mRNA by AnxA2, GIIbeta and a third NR1 mRNA-binding protein, which is yet to be identified. PMID: 21995826
    31. Transcriptional induction of the annexin A2 gene through the direct action of the hypoxia-inducible factor-1 complex is associated with proliferative phase of oxygen-induced retinopathy. PMID: 21788340
    32. Lipid raft endocytosis and exosomal transport facilitate extracellular trafficking of annexin A2 PMID: 21737841
    33. Data show that ANXA2 is part of a novel molecular pathway underlying PDA metastases and a new target for development of PDA therapeutics. PMID: 21572519
    34. in endothelial cells, plasmin specifically induces activation of conventional PKC, which phosphorylates serine 11 and serine 25 of A2, triggering dissociation of the (A2.p11)(2) tetramer. PMID: 21115493
    35. Annexin A2 expression is required for the biologic effects of progastrin in vivo and in vitro. PMID: 20826156
    36. annexin-2 serves as an anchor for CXCL12 to help in the localization of HSCs to the niche PMID: 21108988
    37. These data demonstrate that AnxA2 expression in osteoblasts is under the control of VEGF, which may have implications for both angiogenesis and bone mineralization under low oxygen conditions. PMID: 20817051
    38. Annexin II mediates the binding of anti-dsDNA antibodies to mesangial cells, contributing to the pathogenesis of lupus nephritis. PMID: 20847146
    39. Suggest that TM601, through its interaction with annexin A2, causes suppression and regression of ocular neovascularization and reduces vascular leakage. PMID: 20607799
    40. The modulation of macrophage function by Annexin A2 tetramer is mediated through TLR4. PMID: 19965653
    41. secretion caused by activation of insulin receptor and insulin-like growth factor receptor PMID: 12431980
    42. annexins A1 and A2 bind to dysferlin PMID: 14506282
    43. data establish annexin II as a regulator of cell surface plasmin generation and reveal that impaired endothelial cell fibrinolytic activity constitutes a barrier to effective neoangiogenesis PMID: 14702107
    44. There was a marked increase in the ability of insulin to stimulate recruitment of cmyc-GLUT4 protein to the cell surface. PMID: 14726447
    45. a novel functional role for the RNA-binding properties of annexin A2 in perinuclear localization of mRNA and the association with the cytoskeleton. PMID: 15654879
    46. findings reveal that Anxa2 regulates HSC homing and binding to the bone marrow microenvironment and suggest that Anxa2 is crucial for determining the bone marrow niche of HSCs PMID: 17360942
    47. From its characteristic distribution and molecular features, AX II may be important for myelin function in the PNS. PMID: 17549680
    48. The effect of alcohol on fibrinolysis and plasmin is mediated in part by ANXA2. Alcohol directly influences hepatic pathways of fibrinolysis that may contribute to ALD. PMID: 18289715
    49. Within the endothelial cell, p11 is required for Src kinase-mediated tyrosine phosphorylation of A2, which signals translocation of both proteins to the cell surface. PMID: 18434302
    50. ANXA2 introduces the generation or expression of plasmin, S100A10, and fascin in tumor cells. ANXA2 enhances the development, invasion, and metastasis of tumor. PMID: 18608216

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane.
  • 蛋白家族：
    Annexin family
  • 数据库链接：

    KEGG: mmu:12306

    STRING: 10090.ENSMUSP00000034756

    UniGene: Mm.238343