Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Antizyme inhibitor 2 (Adc)

Recombinant Mouse Antizyme inhibitor 2 (Adc)

  • 货号：
    CSB-YP806915MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP806915MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP806915MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP806915MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP806915MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Azin2
  • Uniprot No.：
  • 别名：
    Azin2; Adc; Odcp; Antizyme inhibitor 2; AzI2; Arginine decarboxylase-like protein; ADC; ARGDC; Ornithine decarboxylase-like protein; ODC-like protein; ornithine decarboxylase paralog; ODC-p
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-459
  • 氨基酸序列
    MAGYLSESDF VMVEEGFSTR DLLEELTLGA SQATSGKVAA FFVADLGAVV RKHFCFLKHL PRVRPFYAVG CNSSLGVLKV LAELGLGFSC ANKAEMELVQ HIGVPASKII CANPCKQVAQ IKYAAKHGVR LLSFDNEVEL AKVVKSHPSA KMVLCIATQD SHSLNHLSLR FGASLKSCRH LLENAKKSHV EVVGVSFHIG SGCPDPQAYA QSIADARLVF QMGEELGHTM NILDLGGGFP GLEGAKVRFE EMASVINSAL DLYFPEGCGV DILAELGRYY VTSAFTVAVS IVAKREVLDQ ASREEQTGAA PKSIVYYLDE GVYGVFNSVL FDNTCPTPAL QKKPSADQPL YSSSLWGPAV EGCDCVAEGL WLPQLQVGDW LVFDNMGAYT VDTKSLLGGT QARRVTYAMS RLAWEALRGQ LLPAEEDQDA EGVCKPLSCG WEITDTLCVG PVFTPASIM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking.
  • 基因功能参考文献：
    1. show, for the first time, an element of polyamine metabolism -AZIN2-, so far described as exclusively devoted to the control of polyamine concentrations, involved in regulating the biosynthesis and content of other amines like serotonin and histamine. PMID: 27084713
    2. in contrast to human ODCp, mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity PMID: 16916800
    3. AZIN2 may have a role in the modulation of reproductory and secretory functions. PMID: 23874910
    4. expression of arginine decarboxylase attenuates oxidative burden in mouse cortical neural stem cells PMID: 20735257
    5. Both endogenous and FLAG-tagged AZIN2 localize to post-Golgi vesicles of the secretory pathway. Immuno-electron microscopy revealed that the vesicles associate mainly with the trans-Golgi network. PMID: 20188728
    6. AZIN2 expression appears to be restricted to brain and testis and it is a labile protein degraded by a ubiquitin-dependent mechanism. PMID: 19956990
    7. granule subtype-specific expression and its induction after MC activation suggest a role for AZIN2 as a local, in situ regulator of polyamine biosynthesis in association with serotonin-containing granules of mast cells PMID: 19718454
    8. AZIN2 affects polyamine homeostasis not only by increasing ornithine decarboxylase activity but also by stimulating polyamine uptake, through negating the inhibitory effect of the antizymes PMID: 18508777
    9. differences in the subcellular distribution of AZIN1 and AZIN2 PMID: 19449338

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Membrane. Cytoplasmic vesicle. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Golgi apparatus, trans-Golgi network. Cytoplasmic granule. Cell projection, axon. Cell projection, dendrite. Perikaryon.
  • 蛋白家族：
    Orn/Lys/Arg decarboxylase class-II family, ODC antizyme inhibitor subfamily
  • 组织特异性：
    Expressed in the medulla and chromaffin cells of the adrenal gland. Expressed in the Langerhans islets of the pancreas. Expressed in the inner part of the seminiferous tubules and in spermatozoa located in the lumen of the epididymis of the testis. Expres
  • 数据库链接：

    KEGG: mmu:242669

    STRING: 10090.ENSMUSP00000030581

    UniGene: Mm.215814