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Recombinant Mouse Arrestin-C (Arr3)

  • 中文名称：
    Recombinant Mouse Arrestin-C(Arr3),Yeast
  • 货号：
    CSB-YP872119MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Arrestin-C(Arr3),Yeast
  • 货号：
    CSB-EP872119MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Arrestin-C(Arr3),Yeast
  • 货号：
    CSB-EP872119MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Arrestin-C(Arr3),Yeast
  • 货号：
    CSB-BP872119MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Arrestin-C(Arr3),Yeast
  • 货号：
    CSB-MP872119MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Arr3
  • Uniprot No.：
  • 别名：
    Arr3; Arrestin-C; Cone arrestin; cArr; Retinal cone arrestin-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-381
  • 氨基酸序列
    MSTVFKKTSS NGKFSIYLGK RDFVDDVDTV EPIDGVVLVD PEYLEGRKLF VRLTCAFRYG RDDLDVIGLT FRKDLYVQTK QVAPAEPTSI QGPLTALQER LLHKLGVNAY PFTLQMVANL PCSVTLQPGP EDSGKPCGVD FEVKSFCAEN LEEKIPKSDS VQLVVRKVQF SALEPGPGPS AQTIRSFFLS SQPLQLQAWM DREVHYHGEA ISVHVSINNY TNKVIRRIKI AVVQTTDVVL YSLDKYTKTV FVQEFTETVA ANSSFSQTFA VTPLLAANCQ KQGLALDGKL KHEDTNLASS TILRPGMNKE LLGILVSYKV RVNLVVSYGG ILGGLPASDV GVELPVILIH PKPSPGERAV ATSSEDIVIE EFMQHNSQTQ S
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins.
  • 基因功能参考文献：
    1. The G-protein coupled receptor, DRD4, requires ARR1 and ARR4 for desensitization and internalization. PMID: 26169958
    2. Data indicate that In arrestin 3 deficient mice, where the alpha2B adrenergic receptor has a stronger binding to spinophilin, the hypertensive response is enhanced. PMID: 26244553
    3. rrestin-3 modulates the activity of ubiquitous JNK1 and JNK2 in non-neuronal cells, impacting the signaling pathway that regulates their proliferation and survival. PMID: 24257757
    4. of arrestin3 to the beta2-adrenergic receptor orchestrates the sequestration of Gq-coupled receptor-induced ERK to the cytosol through direct binding of ERK to arrestin. PMID: 19926878
    5. Data demonstrate that the alpha(2A)AR evokes ERK phosphorylation through both an arrestin/Src-dependent and a Src-independent pathway, both of which are G protein dependent and converge on the Ras-Raf-MEK pathway. PMID: 16809338
    6. These results show that, in MA-10 cells, the hLHR activates Fyn through an arrestin-3-dependent pathway and that this pathway is a mediator of the hLHR-provoked release of EGF-like growth factors. PMID: 18647647

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  • 亚细胞定位：
    Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment.
  • 蛋白家族：
    Arrestin family
  • 组织特异性：
    Inner and outer segments, and the inner plexiform regions of the retina.
  • 数据库链接：

    KEGG: mmu:170735

    STRING: 10090.ENSMUSP00000109398

    UniGene: Mm.95518