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  4. Recombinant Mouse Artemin (Artn)

Recombinant Mouse Artemin (Artn)

  • 货号：
    CSB-YP002160MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP002160MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP002160MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP002160MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP002160MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Artn
  • Uniprot No.：
  • 别名：
    ArtnArtemin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    112-224
  • 氨基酸序列
    AGTRSSRAR TTDARGCRLR SQLVPVSALG LGHSSDELIR FRFCSGSCRR ARSQHDLSLA SLLGAGALRS PPGSRPISQP CCRPTRYEAV SFMDVNSTWR TVDHLSATAC GCLG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.
  • 基因功能参考文献：
    1. HGF supports hindlimb motor neurons through c-Met; CNTF supports subsets of axial motor neurons through CNTFRalpha; and Artemin acts as the first survival factor for parasympathetic preganglionic motor neurons through GFRalpha3/Syndecan-3 activation. PMID: 28270618
    2. RET coupling to ERK and Akt depends strongly on artemin concentration, and it is highest at the low (~100 pM) artemin levels required for neurite outgrowth. PMID: 25635057
    3. We found that artemin, the specific GFRalpha3 ligand that evokes heat hyperalgesia, robustly sensitized cold responses in a TRPM8-dependent manner in mice. PMID: 23884957
    4. artemin lowers the threshold of temperature-dependent itch sensation. PMID: 22770266
    5. a role for the glial-derived neurotrophic factor ARTN in mood disorders is suggested. PMID: 21590285
    6. Increase in levels of artemin and GFRalpha3 regulates C-fiber recruitment after axotomy and regeneration. PMID: 21123573
    7. Artemin-deficient mice revealed abnormalities in the migration and axonal projection pattern of the sympathetic nervous system. Artemin guides sympathetic fibers in following blood vessels as they project toward their final targets. PMID: 12160745
    8. The level of artemin in the skin modulates gene expression and response properties of afferents that project to the skin and these changes lead to behavioral sensitivity to both hot and cold stimuli. PMID: 16914684
    9. These results suggest a potential role for artemin-responsive sensory afferents in mediating sensitivity associated with tissue injury PMID: 18652806
    10. Data report an autocrine/paracrine role of the artemin-GFRA3 signaling system in regulating early embryonic development and apoptosis. PMID: 19580811

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family, GDNF subfamily
  • 数据库链接：

    KEGG: mmu:11876

    STRING: 10090.ENSMUSP00000064521

    UniGene: Mm.56897