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  4. Recombinant Mouse Asialoglycoprotein receptor 2 (Asgr2),Partial

Recombinant Mouse Asialoglycoprotein receptor 2 (Asgr2),Partial

In Stock
  • 货号：
    CSB-EP002208MO1b3
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Asgr2; Asgr-2; Asialoglycoprotein receptor 2; ASGP-R 2; ASGPR 2; Hepatic lectin 2; HL-2; mHL-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Extracellular Domain
  • 来源：
    E.coli
  • 分子量：
    45.9kDa
  • 表达区域：
    80-301aa
  • 氨基酸序列
    QSIQLQEEFRTLKETFSNFSSSTLMEFGALDTLGGSTNAILTSWLAQLEEKQQQLKADHSTLLFHLKHFPMDLRTLTCQLAYFQSNGTECCPVNWVEFGGSCYWFSRDGLTWAEADQYCQLENAHLLVINSREEQDFVVKHRSQFHIWIGLTDRDGSWKWVDGTDYRSNYRNWAFTQPDNWQGHEQGGGEDCAEILSDGHWNDNFCQQVNRWVCEKRRNITH
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：

    The process of expressing the recombinant mouse Asgr2 protein in the E.coli requires the recombinant DNA gene formed by the integration of encoding gene for the 80-301aa of the mouse Asgr2 protein and N-terminal 10xHis-SUMO tag and C-terminal Myc tag sequence, the expression vector that the recombinant DNA gene inserts into, the E.coli that provided the necessary macromolecules and components for transcription and translation of the cloned expression vector. After isolation and purification, this N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged recombinant Asgr2 protein was obtained. This recombinant Asgr2 protein is characterized by high purity (>90%, SDS-PAGE). This Asgr2 protein ran along the gel to the band of approximately 45 kDa molecular weight.

    Asialoglycoprotein receptor 2 (also abbreviated as ASGPR2),a subunit of the Asialoglycoprotein receptor (ASGPR), is a protein encoding by a gene named Asgr2 in mouse and a gene named ASGR2 in human. Asialoglycoprotein receptor (ASGPR) is a receptor specifically expressed by hepatocytes, and it is a highly efficient endocytic receptor. The main function of ASGPR is to remove asialoglycoprotein, apoptotic cells and lipoproteins in the blood circulation system. In addition to asialoceruloplasmin, ASGPR can also bind to many other asialoglycoproteins, such as erythropoietin, interferon, thyroglobulin, transferrin, hepatoglobulin, fetuin, prothrombin and so on.

  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
  • 基因功能参考文献：
    1. ASGP-R2 mediates the clearance of glycoproteins that bear oligosaccharides terminating with Siaalpha2,6Gal and thereby helps maintain the relative concentrations of these glycoproteins in the blood. PMID: 19075021
  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein.
  • 组织特异性：
    Expressed exclusively in hepatic parenchymal cells.
  • 数据库链接：

    KEGG: mmu:11890

    STRING: 10090.ENSMUSP00000099632

    UniGene: Mm.1357