Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse B-cell CLL/lymphoma 6 member B protein (Bcl6b)

Recombinant Mouse B-cell CLL/lymphoma 6 member B protein (Bcl6b)

  • 货号：
    CSB-YP002626MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP002626MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP002626MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP002626MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP002626MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Bcl6b
  • Uniprot No.：
  • 别名：
    Bcl6b; BazfB-cell CLL/lymphoma 6 member B protein; Bcl6-associated zinc finger protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-474
  • 氨基酸序列
    MGSTAAPEGA LGYVREFTRH SSDVLSNLNE LRLRGILTDV TLLVGGQPLR AHKAVLIACS GFFYSIFRGR AGLGVDVLSL PGGPEARGFA PLLDFMYTSR LRLSPATAPA VLAAATYLQM EHVVQACHRF IQASYEPLGI SLRPVEVEPP RPPTVAPPGS PRRSEGHPDP PTESRSCSQG SPSPASPDPK ACNWKKYKFI VLNSQTSQAG SLVGESSGQP CPQARLPSGD EACSSSSSSE EGTTPGLQSR LSLATTTARF KCGALANNSY LFTPRAQETS LPASKQANPP PGSEFFSCQN CEAVAGCSSG LELLAPGDED KPYKCQLCRS AFRYKGNLAS HRTVHTGEKP YRCSICGARF NRPANLKTHS RIHSGEKPYK CETCGSRFVQ VAHLRAHVLI HTGEKPYPCP TCGTRFRHLQ TLKSHVRIHT GEKPYHCDPC GLHFRHKSQL RLHLRQKHGA ATNTKVRYHI LGGP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a sequence-specific transcriptional repressor in association with BCL6. Necessary for activation of naive T-cells to antigenic stimulation. May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6.
  • 基因功能参考文献：
    1. Mouse germline stem (GS) cell transfected with an activated form of Map2k1 have upregulated Etv5 and Bcl6b gene expression. PMID: 22491947
    2. represses Bcl6-dependent transcription. PMID: 12659862
    3. BCL6b is required for the enhanced magnitude of the secondary response of memory CD8(+) T cells. PMID: 15833813
    4. Both BCL-6 and BAZF regulate hematopoietic progenitor cells homeostasis by an indirect pathway involving CD8 T cells. PMID: 17526724
    5. GDNF up-regulation of Bcl6b, Erm, and Lhx1 expression through Src family kinase signaling is a key component of the intracellular mechanism for spermatogonial stem cells self-renewal. PMID: 17597063
    6. DNA-binding protein; gene expression regulation; binds STAT6 elements; binding site specificity PMID: 11374866

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Ubiquitously expressed with higher expression found in heart and lung.
  • 数据库链接：

    KEGG: mmu:12029

    STRING: 10090.ENSMUSP00000000326

    UniGene: Mm.12930