Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse BAG family molecular chaperone regulator 1 (Bag1)

Recombinant Mouse BAG family molecular chaperone regulator 1 (Bag1)

  • 货号：
    CSB-YP726670MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP726670MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP726670MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP726670MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP726670MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Bag1BAG family molecular chaperone regulator 1; BAG-1; Bcl-2-associated athanogene 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-355
  • 氨基酸序列
    MAGRSAARRP RGDREPLGPR LRAPRPAREP RQSESRAERG LPPSQRSSVR SAASGHDRST RGAPAGACKP RVKKKVRPRS SQSEKVGSSS RELTRSKKVT RSKNVTGTQV EEVTKIEEAT QTEEVTVAEE VTQTDNMAKT EEMVQTEEME TPRLSVIVTH SNERYDLLVT PQQGNSEPVV QDLAQLVEEA TGVPLPFQKL IFKGKSLKEM ETPLSALGMQ NGCRVMLIGE KSNPEEEVEL KKLKDLEVSA EKIANHLQEL NKELSGIQQG FLAKELQAEA LCKLDRKVKA TIEQFMKILE EIDTMVLPEQ FKDSRLKRKN LVKKVQVFLA ECDTVEQYIC QETERLQSTN LALAE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.
  • 基因功能参考文献：
    1. These results provide evidence for an emerging role of BAG-1M in the regulation of BACE1 expression and AD pathogenesis and that targeting the BAG-1M-NF-kappaB complex may provide a mechanism for inhibiting Abeta production and plaque formation. PMID: 28502705
    2. that BAG-1L over-expression protects against hypoxia/re-oxygenation injury, at least in part, by interacting with HSP70, and by accelerating the activation of PI3K/AKT pathways PMID: 28523530
    3. These studies demonstrate for the first time the significance of BAG-1-mediated protein-protein interactions. PMID: 27633857
    4. The BAG-1 stabilizes F508del-CFTR by direct binding, probably competing out ubiquitin to partially avoid its proteasomal degradation. PMID: 23178238
    5. The membrane form of heparin binding EGF-like growth factor (ProHB-EGF) is most likely able to trigger the nuclear translocation of BAG-1 in keeping its level high. PMID: 24628338
    6. Hemoxygenase 1 deficiency provoked diminished Bag-1 level upon LPS treatment PMID: 23521418
    7. this study first reported the solution structure of mBAG-1-UBH and the growth factor precursor-interacting motif on the protein. PMID: 23277101
    8. Bag-1 proteins function as regulators of the action of selective transcription factors. PMID: 20858459
    9. during development of mouse autopods, BAG-1 expression is downregulated upon the initiation of interdigital apoptosis (BAG-1) PMID: 11804787
    10. Bag1 is a regulator and marker of neuronal differentiation PMID: 11965493
    11. BAG1 displays potent neuroprotective activity in vivo against stroke. PMID: 14655755
    12. Since, BAG-1 is essential for cell survival, its association with tNhtt aggregates might disrupt its normal function and thereby promote polyglutamine-expanded tNhtt-induced cell death. PMID: 15781153
    13. Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. PMID: 16116448
    14. Modulation of Bag-1 expression can therefore mediate chondrocyte differentiation and turnover PMID: 17950682
    15. BAG-1 associates with Tau protein in an Hsc70-dependent manner. PMID: 17954934
    16. BAG1 plays a key role in affective resilience and in regulating recovery from both manic-like and depression-like behavioral impairments PMID: 18562287
    17. These data suggest a role for BAG-1 in mechanisms of neurogenesis in the adult mouse brain. PMID: 19084526
    18. The longer p50 isoform is generated through use of an upstream, in-frame, non-AUG translation initiation codon. PMID: 9396724
    19. Alternate protein isoforms arise through the use of a non-AUG (CUG) codon in addition to two downstream in-frame AUG codons. PMID: 9679980

    显示更多

    收起更多

  • 亚细胞定位：
    [Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm.
  • 组织特异性：
    Isoform 2 is expressed in the heart, lung, kidney and spinal cord. Isoform 1 and isoform 2 are expressed in hematopoietic cell lines. The levels of isoform 2 are relatively constant in all the cell lines examined while the levels of isoform 1 are more var
  • 数据库链接：

    KEGG: mmu:12017

    STRING: 10090.ENSMUSP00000030125

    UniGene: Mm.688