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Recombinant Mouse BRCA2 and CDKN1A-interacting protein (Bccip)

  • 中文名称：
    Recombinant Mouse BRCA2 and CDKN1A-interacting protein(Bccip),Yeast
  • 货号：
    CSB-YP887452MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse BRCA2 and CDKN1A-interacting protein(Bccip),Yeast
  • 货号：
    CSB-EP887452MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse BRCA2 and CDKN1A-interacting protein(Bccip),Yeast
  • 货号：
    CSB-EP887452MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse BRCA2 and CDKN1A-interacting protein(Bccip),Yeast
  • 货号：
    CSB-BP887452MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse BRCA2 and CDKN1A-interacting protein(Bccip),Yeast
  • 货号：
    CSB-MP887452MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Bccip
  • Uniprot No.：
  • 别名：
    BccipBRCA2 and CDKN1A-interacting protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-316
  • 氨基酸序列
    MASKAKKRAV GNGIQRPLGA PGQREEEEEE EDEVEDEEED EDDSDEEEDE VDEIVDEEVN IEFEAYSISD NDYGGIKKLL QQLFLKAPVN TAELTNLLMQ QNHIGSVIKQ TDVSEDSDDE VDEDEIFGFI SLLNLTERKG TQCAEQIKEL VLSFCEKTCE QSMVEQLDKL LNDTSKPVGL LLSERFINVP PQIALPMHQQ LQKELSEARR TNKPCGKCCF YLLISKTFME AGKSSSRKRQ DSLQQGALMF ANAEEEFFYE KAILKFSYSV QGESDTRLGG RWSFDDVPMT PLRTVMVIPD DRMNEIMETL KDHLSV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
  • 基因功能参考文献：
    1. We analyzed the BCCIP protein level in 470 cases of human breast cancer to determine the associations between BCCIP and 53BP1, p53, and subtypes of breast cancer. We further constructed a unique BCCIP knockdown mouse model to determine whether a partial BCCIP deficiency leads to spontaneous breast cancer formation PMID: 29047390
    2. BCCIP represents a paradoxical class of modulators for tumorigenesis as a suppressor for initiation but a requisite for progression. PMID: 24145349
    3. BCCIP and its anti-replication stress functions are essential for normal neural development by maintaining an orderly proliferation of neural progenitors. PMID: 22292003
    4. these data suggest a unique function of BCCIP, not only in repair of DNA damage, but also in resolving stalled replication forks and prevention of replication stress PMID: 21966279
  • 亚细胞定位：
    Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole.
  • 蛋白家族：
    BCP1 family
  • 数据库链接：

    KEGG: mmu:66165

    STRING: 10090.ENSMUSP00000033282

    UniGene: Mm.389983