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  4. Recombinant Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (Tnfaip1)

Recombinant Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (Tnfaip1)

  • 货号：
    CSB-YP023956MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP023956MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP023956MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP023956MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP023956MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tnfaip1
  • Uniprot No.：
  • 别名：
    Tnfaip1; Edp1BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1; Tumor necrosis factor; alpha-induced protein 1; endothelial
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-316
  • 氨基酸序列
    MSGDTCLCPA SGAKPKISGF KGGGLGNKYV QLNVGGSLYY TTVRALTRHD TMLKAMFSGR MEVLTDKEGW ILIDRCGKHF GTILNYLRDD TITLPQSRQE IQELMAEAKY YLIQGLVSTC QTALQDKKDS YQPVCNIPII TSLREEDRLI ESSTKPVVKL LYNRSNNKYS YTSNSDDHLL KNIELFDKLS LRFNGRVLFI KDVIGDEICC WSFYGQGRKL AEVCCTSIVY ATEKKQTKVE FPEARIYEET LNVLLYETPR VPDNSLLEAT SRSRSQASPS EDEDTFELRD RVRRIHVKRY STYDDRQLGH QSTHRD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.
  • 基因功能参考文献：
    1. Results demonstrated that TNFAIP1 was significantly upregulated by Abeta25-35 in mouse primary cortical neurons and N2a cells, and TNFAIP1 may be a key player that mediated Abeta25-35-induced neurotoxicity by inactivating the Akt/CREB signaling pathway, and in turn downregulating anti-apoptotic protein Bcl-2. PMID: 27430312
    2. ABETA 25-35 downregulated miR-137 and upregulated TNFAIP1 in cortical neurons and N2a cells. PMID: 28655611
    3. Study identifies Bacurd1/Kctd13 and Bacurd2/Tnfaip1 as interacting partners to RhoA GTPase proteins which influence the development of cortical neurons. PMID: 26969432
    4. Bacurd2 influences the multipolar-to-bipolar transition of radially migrating neurons in a cell autonomous fashion. Bacurd2 and Rnd2 interact to promote radial migration within the embryonic cortex. PMID: 25888806
    5. Estrogen and ERbeta regulate Tnfaip1 expression in mouse hippocampus. PMID: 24737445

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Endosome.
  • 蛋白家族：
    BACURD family
  • 数据库链接：

    KEGG: mmu:21927

    STRING: 10090.ENSMUSP00000017759

    UniGene: Mm.386774