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Recombinant Mouse Beta-casein (Csn2)

  • 中文名称：
    Recombinant Mouse Beta-casein(Csn2),Yeast
  • 货号：
    CSB-YP006063MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Beta-casein(Csn2),Yeast
  • 货号：
    CSB-EP006063MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Beta-casein(Csn2),Yeast
  • 货号：
    CSB-EP006063MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Beta-casein(Csn2),Yeast
  • 货号：
    CSB-BP006063MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Beta-casein(Csn2),Yeast
  • 货号：
    CSB-MP006063MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Csn2
  • Uniprot No.：
  • 别名：
    Csn2; Csnb; Beta-casein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    16-231
  • 氨基酸序列
    RETTF TVSSETDSIS SEESVEHINE QKLQKVNLMG QLQAEDVLQA KVHSSIQSQP QAFPYAQAQT ISCNPVPQNI QPIAQPPVVP SLGPVISPEL ESFLKAKATI LPKHKQMPLL NSETVLRLIN SQIPSLASLA NLHLPQSLVQ LLAQVVQAFP QTHLVSSQTQ LSLPQSKVLY FLQQVAPFLP QDMSVQDLLQ YLELLNPTVQ FPATPQHSVS V
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Important role in determination of the surface properties of the casein micelles.
  • 基因功能参考文献：
    1. These results indicate that PRL, EGF and glucocorticoids have distinct roles in the establishment of beta-casein secretion pathway. PMID: 27836773
    2. Dexamethasone signaling upregulates Claudin-3 and -4 without beta-casein expression. Prolactin and dexamethasone signaling synergistically upregulate beta-casein expression. PMID: 27130254
    3. octamer-binding transcription factor-1 may serve as a master regulator that facilitates the DNA binding of both signal transducer and activator of transcription 5 and glucocorticoid receptor in hormone-induced beta-casein expression PMID: 23313770
    4. mammary cells express beta-casein in response to prolactin in a pathway that involves gap junction intracellular communication and OCT-1 and is independent of STAT5 nuclear translocation PMID: 22142338
    5. Progesterone receptor directly inhibits beta-casein gene transcription in mammary epithelial cells through promoting promoter and enhancer repressive chromatin modifications PMID: 21527503
    6. Our data thus suggest that the degradation of beta-casein occurs via the microautophagic pathway. PMID: 20182891
    7. In vitro expression of recombinant basement membrane-mediated beta-casein gene can be controlled pharmacologically by histone deacetylase inhibitors or by overexpression of a histone acetylase enzyme. PMID: 11746508
    8. Elevated levels of beta-casein gene expression were found in transgenic mice with stat5 during late pregnancy and lactation. PMID: 12496367
    9. the first intron of the murine beta-casein gene contains a functional promoter, and beta-casein has intronic enhancer elements PMID: 12821156
    10. Liver-enriched inhibitory protein plays critical role in mediating TNF-induced down-regulation of the beta-casein gene. PMID: 14976147
    11. The ubiquitous Oct-1 transcription factor may be involved in hormonally regulated, tissue-specific beta-casein gene expression. PMID: 16965262
    12. a negative cross talk between PR and Stat5a/GR may contribute to the physiological role of progesterone to repress lactogenic hormone induction of the beta-casein gene PMID: 16973758
    13. These results demonstrate that TGF-beta abrogates prolactin-stimulated beta-casein gene expression in mammary epithelial cells through, at least in part, a Smad3-dependent mechanism. PMID: 18335503
    14. the interaction of glucocorticoid receptor with Oct-1 on the beta-casein gene promoter PMID: 19266165
    15. The developmental regulation of DNA looping between the beta-casein regulatory regions was observed in lactating but not in virgin mouse mammary glands. PMID: 19542223

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Beta-casein family
  • 组织特异性：
    Mammary gland specific. Secreted in milk.
  • 数据库链接：

    KEGG: mmu:12991

    STRING: 10090.ENSMUSP00000080976

    UniGene: Mm.268737