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  4. Recombinant Mouse Beta-catenin-interacting protein 1 (Ctnnbip1)

Recombinant Mouse Beta-catenin-interacting protein 1 (Ctnnbip1)

  • 货号：
    CSB-YP867500MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP867500MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP867500MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP867500MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP867500MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ctnnbip1; Catnbip1; Icat; Beta-catenin-interacting protein 1; Inhibitor of beta-catenin and Tcf-4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-81
  • 氨基酸序列
    MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVSS QLSQLPQHSI DQGAEDVVMA FSRSETEDRR Q
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.
  • 基因功能参考文献：
    1. miR-215-5p is a negative regulator of adipocyte differentiation through post-transcriptional regulation of FNDC3B and CTNNBIP1 during early adipogenesis PMID: 27521659
    2. miR-29b plays a pivotal role in fetal mouse neurogenesis by regulating ICAT-mediated Wnt/beta-catenin signaling. PMID: 25321480
    3. Overexpression of Icat induces G(2) arrest and cell death in tumor cell mutants for adenomatous polyposis coli, beta-catenin, or Axin. PMID: 12036951
    4. ICAT plays an important role in the anteriorization of neural cells by inhibiting the posteriorizing activity of Wnt signaling PMID: 15148409
    5. These results suggest that the loss of ICAT gene function causes the arrest of UB branching and the apoptotic death of MM cells, resulting in renal agenesis. PMID: 17803964
    6. Inhibition of beta-catenin signaling in articular chondrocytes causes increased cell apoptosis and articular cartilage destruction in Col2a1-ICAT- transgenic mice. PMID: 18576323

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CTNNBIP1 family
  • 组织特异性：
    Highly expressed in heart, brain, liver and skeletal muscle. Detected at low levels in kidney, testis and lung.
  • 数据库链接：

    KEGG: mmu:67087

    STRING: 10090.ENSMUSP00000030839

    UniGene: Mm.299735