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  4. Recombinant Mouse Bone morphogenetic protein 10 (Bmp10)

Recombinant Mouse Bone morphogenetic protein 10 (Bmp10)

  • 货号：
    CSB-YP002734MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP002734MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP002734MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP002734MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP002734MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Bmp10
  • Uniprot No.：
  • 别名：
    Bmp10Bone morphogenetic protein 10; BMP-10
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    314-421
  • 氨基酸序列
    NAKGNYC KKTPLYIDFK EIGWDSWIIA PPGYEAYECR GVCNYPLAEH LTPTKHAIIQ ALVHLKNSQK ASKACCVPTK LDPISILYLD KGVVTYKFKY EGMAVSECGC R
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
  • 基因功能参考文献：
    1. our data show that in a tumor environment BMP9 and BMP10 play different roles and thus blocking their shared receptor ALK1 is maybe not appropriate. Indeed, BMP9, but not BMP10, acts as a quiescence factor on tumor growth, lung metastasis and vessel normalization. PMID: 30165893
    2. CV2 binds directly to BMP10, as determined by co-immunoprecipitation, and inhibits BMP10 from initiating SMAD signaling, as determined by luciferase reporter gene assays. BMP10 and CV2 have important roles in coordinating cardiomyogenesis in progenitor cells. PMID: 28464239
    3. The Prodomain-bound Form of Bone Morphogenetic Protein 10 Is Biologically Active on Endothelial Cells. PMID: 26631724
    4. result was supported by the identification of the regulation by BMP9 and BMP10 of several genes known to be involved in this process PMID: 26056270
    5. BMP10 has an exclusive function in cardiac development, which cannot be substituted by BMP9. PMID: 23812757
    6. Myocardin transactivated Bmp10 via binding of a serum response factor-myocardin complex to a nonconsensus CArG element in the Bmp10 promoter. A myocardin/BMP10 signaling pathway regulates cardiomyocyte proliferation & apoptosis in embryonic heart. PMID: 22996691
    7. BMP9 and BMP10 are important in postnatal vascular remodeling of the retina and BMP10 can substitute for BMP9. PMID: 22566602
    8. the BMP10-Tbx20 signaling cascade is important for ventricular wall development and maturation. PMID: 21890625
    9. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. PMID: 21737454
    10. Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10. PMID: 21550985
    11. Results describe an essential role of bone morphogenetic protein 10 in regulating cardiac growth and chamber maturation. PMID: 15073151
    12. bone morphogenetic protein 10 in myocardium has a role in cardiac postnatal hypertrophic growth PMID: 16798733

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 组织特异性：
    In the embryo, expressed exclusively in the ventricular trabecular myocardium of the developing heart from 9.0 dpc-13.5 dpc. By 16.5 dpc-18.5 dpc, only detectable in atria. Highly expressed in the adult heart where it is found in the right atrium but not
  • 数据库链接：

    KEGG: mmu:12154

    STRING: 10090.ENSMUSP00000032125

    UniGene: Mm.483321