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  4. Recombinant Mouse Bone morphogenetic protein 5 (Bmp5)

Recombinant Mouse Bone morphogenetic protein 5 (Bmp5)

  • 中文名称：
    Recombinant Mouse Bone morphogenetic protein 5(Bmp5),Yeast
  • 货号：
    CSB-YP002741MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Bone morphogenetic protein 5(Bmp5),Yeast
  • 货号：
    CSB-EP002741MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Bone morphogenetic protein 5(Bmp5),Yeast
  • 货号：
    CSB-EP002741MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Bone morphogenetic protein 5(Bmp5),Yeast
  • 货号：
    CSB-BP002741MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Bone morphogenetic protein 5(Bmp5),Yeast
  • 货号：
    CSB-MP002741MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Bmp5; Bmp-5; Bone morphogenetic protein 5; BMP-5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    315-452
  • 氨基酸序列
    AASKRK NQNRNKSNSH QDPSRMPSAG DYNTSEQKQA CKKHELYVSF RDLGWQDWII APEGYAAFYC DGECSFPLNA HMNATNHAIV QTLVHLMFPD HVPKPCCAPT KLNAISVLYF DDSSNVILKK YRNMVVRSCG CH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation.
  • 基因功能参考文献：
    1. Data conclude that BMP-5 has stage-specific role to play during MC3T3E1 osteoblast differentiation in part by autocrine p38/Runx2/COLIA1 signaling. PMID: 28497879
    2. Bmp5 gene thus contains an "injury response" control region that is distinct from embryonic enhancers, and that is activated by multiple types of injury in adult animals PMID: 25886903
    3. Early endothelial outgrowth cells act protective in diabetic nephropathy, and such effects are significantly stimulated by BMP-5 PMID: 25080521
    4. BMP-5 acts as a potent endothelial outgrowth cells agonist in murine AKI in the short and mid to long term PMID: 23678046
    5. Bone morphogenetic protein 5 regulates the number of keratinocyte stem cells from the skin of mice. PMID: 21179110
    6. Data indicate that locus coeruleus development requires either Bmp5 or Bmp7, and one is able to compensate for the loss of the other. PMID: 20493948
    7. Variability in gene expression of BMP5 may be an important contributor to osteoarthritis genetic susceptibility PMID: 20021689
    8. BMP5 is required not only for skeletal patterning during embryonic development, but also for bone response and remodeling to mechanical stimulation at specific anatomic sites in the skeleton PMID: 18380899
    9. Bmp5 is expressed in many skeletal precursors and different enhancers control expression in individual bones. PMID: 19096511

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 数据库链接：

    KEGG: mmu:12160

    STRING: 10090.ENSMUSP00000012281

    UniGene: Mm.428950