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  4. Recombinant Mouse C-terminal-binding protein 2 (Ctbp2)

Recombinant Mouse C-terminal-binding protein 2 (Ctbp2)

  • 中文名称：
    Recombinant Mouse C-terminal-binding protein 2(Ctbp2),Yeast
  • 货号：
    CSB-YP006136MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse C-terminal-binding protein 2(Ctbp2),Yeast
  • 货号：
    CSB-EP006136MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse C-terminal-binding protein 2(Ctbp2),Yeast
  • 货号：
    CSB-EP006136MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse C-terminal-binding protein 2(Ctbp2),Yeast
  • 货号：
    CSB-BP006136MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse C-terminal-binding protein 2(Ctbp2),Yeast
  • 货号：
    CSB-MP006136MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ctbp2C-terminal-binding protein 2; CtBP2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-445
  • 氨基酸序列
    MALVDKHKVK RQRLDRICEG IRPQIMNGPL HPRPLVALLD GRDCTVEMPI LKDLATVAFC DAQSTQEIHE KVLNEAVGAM MYHTITLTRE DLEKFKALRV IVRIGSGYDN VDIKAAGELG IAVCNIPSAA VEETADSTVC HILNLYRRNT WLYQALREGT RVQSVEQIRE VASGAARIRG ETLGLIGFGR TGQAVAVRAK AFGFSVIFYD PYLQDGIERS LGVQRVYTLQ DLLYQSDCVS LHCNLNEHNH HLINDFTIKQ MRQGAFLVNA ARGGLVDEKA LAQALKEGRI RGAALDVHES EPFSFAQGPL KDAPNLICTP HTAWYSEQAS LEMREAAATE IRRAITGRIP ESLRNCVNKE FFVTSAPWSV IDQQAIHPEL NGATYRYPPG IVGVAPGGLP PAMEGIIPGG IPVTHNLPTV AHPSQAPSPN QPTKHGDNRE HPNEQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Corepressor targeting diverse transcription regulators. Isoform 2 probably acts as a scaffold for specialized synapses. Functions in brown adipose tissue (BAT) differentiation.
  • 基因功能参考文献：
    1. The s postulate that RIBEYE disruption is partially compensated by several small active zone organization at each synaptic contact between inner hair cells and spiral ganglion neurons. PMID: 29328020
    2. studies revealed a new epigenetic pathway in the control of IL-2 production in systemic lupus erythematosus whereby low levels of miR-200a-3p accumulate the binding of the ZEB1-CtBP2 complex to the IL-2 promoter and suppress IL-2 production PMID: 28438897
    3. Our results show that RIBEYE is essential for synaptic ribbons as such, and may organize presynaptic nano-domains that position release-ready synaptic vesicles adjacent to Ca(2+) channels PMID: 26929012
    4. Ctbp2 preoccupies regions in active genes with the NuRD complex in undifferentiated ESCs that are directed toward H3K27me3 by PRC2 to induce stable silencing, which is pivotal for natural lineage commitment. PMID: 25944056
    5. Phosphorylation of KLF3 and CtBP2 by HIPK2 strengthens the interaction between these two factors and increases transcriptional repression by KLF3. PMID: 25659434
    6. propose that Zscan4 may regulate gene transcription in mouse ES cells through interaction with LSD1 and CtBP2 PMID: 24594919
    7. RIBEYE(B) interacts with ArfGAP3 in vivo and in vitro. PMID: 24719103
    8. CTBP2 is indispensable to create a chromatin environment conducive for RAR/RXR-mediated transcription by recruiting the histone acetyltransferase p300. PMID: 23775127
    9. Study demonstrates differential regional and subcellular expression patterns for the two CtBP family members in brain and reveals a previously unknown synaptic localization for CtBP2 in particular brain regions. PMID: 22745816
    10. Ctbp2 has a role in maintaining a balance in decisions to self-renewal and differentiate in embryonic stem cells and mesodermal progenitors PMID: 19825414
    11. The CtBP2 co-repressor function is regulated by an NADH-dependent effect on CtBP2 dimerization. PMID: 15037661
    12. calsenilin and CtBP2 are present in synaptic vesicles and can interact in vivo PMID: 16787403
    13. These results identify a new CtBP interaction motif and establish ZNF217 as a transcriptional repressor protein that functions, at least in part, by associating with CtBP. PMID: 16940172
    14. These results demonstrate that the PXDLS binding cleft is functionally important but suggest that it is primarily required for localization of the CtBP2 complex to promoter-bound transcription factors. PMID: 16940173
    15. analysis of the CtBP2 corepressor complex induced by E1A and modulation of E1A transcriptional activity by CtBP2 PMID: 17023432
    16. E1A may gain access to cellular promoters through conservved sequence-dependent interaction with CtBP2. PMID: 17546044
    17. cooperates with ZEB1 and HDAC1 to suppress IL-2 gene activation in T cells PMID: 19181930

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  • 亚细胞定位：
    Nucleus. Cell junction, synapse.
  • 蛋白家族：
    D-isomer specific 2-hydroxyacid dehydrogenase family
  • 组织特异性：
    Found in all tissues except spleen and liver.
  • 数据库链接：

    KEGG: mmu:13017

    STRING: 10090.ENSMUSP00000130294

    UniGene: Mm.246240