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  4. Recombinant Mouse C-type lectin domain family 2 member I (Clec2i), partial

Recombinant Mouse C-type lectin domain family 2 member I (Clec2i), partial

  • 中文名称：
    Recombinant Mouse C-type lectin domain family 2 member I(Clec2i),partial,Yeast
  • 货号：
    CSB-YP896263MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse C-type lectin domain family 2 member I(Clec2i),partial,Yeast
  • 货号：
    CSB-EP896263MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse C-type lectin domain family 2 member I(Clec2i),partial,Yeast
  • 货号：
    CSB-EP896263MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse C-type lectin domain family 2 member I(Clec2i),partial,Yeast
  • 货号：
    CSB-BP896263MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse C-type lectin domain family 2 member I(Clec2i),partial,Yeast
  • 货号：
    CSB-MP896263MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Clec2i
  • Uniprot No.：
  • 别名：
    Clec2i; Clrg; Dcl1; Ocilrp2C-type lectin domain family 2 member I; C-type lectin-related protein DCL1; C-type lectin-related protein G; Clr-g; Lymphoid-derived C-type lectin-1; LCL-1; Osteoclast inhibitory lectin-related protein 2; Ocil-related protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits osteoclast formation. Receptor for KLRB1F. Enhances T-cell activation. Plays a role in splenocyte activation, T-cell responses and IL-2 production.
  • 基因功能参考文献：
    1. Data show OCILRP2 binding to DAP12 resulting in Raf-MAP kinase pathways activation and T-cell activation. PMID: 25411776
    2. OCILRP2 is a regulator of dendritic cells maturation and differentiation following TLR4 activation. PMID: 24631687
    3. The electrostatic profile of NKR-P1F is complementary to that of Clr-g, which suggests a plausible interaction mechanism based on contacts between surface sites of opposite potential. PMID: 23071282
    4. studies reveal a unique functional interaction between two C-type lectins, OCILRP2/Clr-g and NKRP1f, during APC-mediated T cell costimulation and suggest a role for C-type lectins in maintaining T cell response or memory in vivo PMID: 15963483
    5. May facilitate lipid rafts and immunological synapse formation during T cell interaction with antigen presenting cells. PMID: 16143319
    6. Identification of a novel family of genes, named Clr, encoding C-type lectin-like molecules, which maps in the natural killer (NK) gene complex (NKC) on mouse Chromosome 6. PMID: 11398965
    7. mouse Nkrp1d and Nkrp1f bind specific C-type lectin-related (Clr) molecules. Nkrp1d mediated inhibition when recognizing Clrb, a molecule expressed in dendritic cells and macrophages. Nkrp1 and Clr are intertwined in a genetically conserved NKC region. PMID: 12858173

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 组织特异性：
    Detected in osteoblasts, growth plate chondrocytes and skeletal muscle overlying the bone (at protein level). Detected in spleen, B-cells, dendritic cells, thymus, and in IL2-activated natural killer cells.
  • 数据库链接：

    KEGG: mmu:93675

    STRING: 10090.ENSMUSP00000032519

    UniGene: Mm.391513