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  4. Recombinant Mouse CB1 cannabinoid receptor-interacting protein 1 (Cnrip1)

Recombinant Mouse CB1 cannabinoid receptor-interacting protein 1 (Cnrip1)

  • 中文名称：
    Recombinant Mouse CB1 cannabinoid receptor-interacting protein 1(Cnrip1)
  • 货号：
    CSB-YP705797MO
  • 规格：
    ￥2208
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
      The reducing (R) protein migrates as 26 kDa in SDS-PAGE may be due to glycosylation.
      Recommended Product
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cnrip1CB1 cannabinoid receptor-interacting protein 1; CRIP-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length
  • 来源：
    Yeast
  • 分子量：
    22.6 kDa
  • 表达区域：
    1-464aa
  • 氨基酸序列
    MGDLPGLVRLSIALRIQPNDGPVFFKVDGQRFGQNRTIKLLTGSSYKVEVKIKPTTLQVENISIGGVLVPLELKGKEPDGERVVYTGIYDTEGVAPTKSGERQPIQITMPFTDIGTFETVWQVKFYNYHKRDHCQWGSPFSVIEYECKPNETRSLMWVNKESFL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer，50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.
  • 基因功能参考文献：
    1. Ddata indicate that cannabinoid receptor-interacting protein 1a enhances hippocampal cannabinoid type 1 receptor signaling in vivo. PMID: 25772509
    2. These studies demonstrate a novel role for CRIP1a in agonist-driven CB1 R cell surface regulation postulated to occur by two mechanisms: 1) attenuating internalization that is agonist-mediated, but not that in the absence of exogenous agonists, and 2) biased agonist-dependent trafficking of de novo synthesized receptor to the cell surface PMID: 27513693
    3. Endogenous levels of CRIP1a modulate CB1R-mediated signal transduction by facilitating a Gi/o protein subtype preference for Gi1 and Gi2, accompanied by an overall suppression of G-protein-mediated signaling in neuronal cells. PMID: 25446256
    4. CRIP1a appears to act as a broad negative regulator of CB1 receptor function PMID: 25657338
  • 蛋白家族：
    CNRIP family
  • 组织特异性：
    Highly expressed in brain. Also detected in heart, lung, intestine, kidney, testis, spleen, liver and muscle (at protein level).
  • 数据库链接：

    KEGG: mmu:380686

    UniGene: Mm.425666