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  4. Recombinant Mouse CD209 antigen-like protein A (Cd209a), partial

Recombinant Mouse CD209 antigen-like protein A (Cd209a), partial

  • 中文名称：
    Recombinant Mouse CD209 antigen-like protein A(Cd209a),partial,Yeast
  • 货号：
    CSB-YP852823MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse CD209 antigen-like protein A(Cd209a),partial,Yeast
  • 货号：
    CSB-EP852823MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse CD209 antigen-like protein A(Cd209a),partial,Yeast
  • 货号：
    CSB-EP852823MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse CD209 antigen-like protein A(Cd209a),partial,Yeast
  • 货号：
    CSB-BP852823MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse CD209 antigen-like protein A(Cd209a),partial,Yeast
  • 货号：
    CSB-MP852823MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cd209a
  • Uniprot No.：
  • 别名：
    Cd209a; CireCD209 antigen-like protein A; Dendritic cell-specific ICAM-3-grabbing non-integrin; DC-SIGN; CD antigen CD209
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens.
  • 基因功能参考文献：
    1. M. scrofulaceum induces a semimature DC phenotype that is characterized by PD-L2 over-expression and elevated synthesis of IL-10, most likely through TLR4 and Raf-1 signaling pathway-dependent DC-SIGN stimulation. PMID: 27450002
    2. results suggested that podocytes in lupus nephritis can exert dendritic cell-like function through their expression of DC-SIGN, which may be involved in immune and inflammatory responses of renal tissues PMID: 26440060
    3. results indicate that SIGN-R1 and complement factors play an important role in the systemic clearance of radiation-induced apoptotic innate immune cells to maintain tissue homeostasis after gamma-irradiation PMID: 26079881
    4. High-resolution crystal structures of the SIGN-R1 carbohydrate recognition domain show 2 binding sites allowing SIGNR1 to simultaneously bind both immune glycoproteins and microbial polysaccharide components. PMID: 25450767
    5. Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics. PMID: 26106150
    6. Intestinal enterocytes regulate tissue-associated immune compartments under the control of DC-SIGN in inflammatory bowel disease. PMID: 25574091
    7. In vivo T cell activation induces the formation of CD209(+) PDL-2(+) dendritic cells. PMID: 24098455
    8. CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis. PMID: 24729611
    9. CD209a is activated in macrophages by LECT2. PMID: 23254286
    10. The neck region of the C-type lectin DC-SIGN regulates its surface spatiotemporal organization and virus-binding capacity on antigen-presenting cells PMID: 23019323
    11. interactions between the CRD of DC-SIGN and the extracellular matrix and/or cis interactions with transmembrane scaffolding protein(s) play an essential role in organizing these microdomains PMID: 22292921
    12. analysis of activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and beta2 integrins PMID: 22396536
    13. Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation. PMID: 21860028
    14. SIGN-R1 is critical in the regulation of immune responses. PMID: 21529282
    15. SIGN-R1 is expressed on a subset of macrophage receptor with a collagenous structure (MARCO-positive) macrophages. This subset is diminished when marginal zone (MZ) B cells are absent due to genetic developmental defects or B cell migration out of the MZ. PMID: 21257969
    16. Fully differentiated monocyte-derived DCs (Mo-DCs) develop in mice and DC-SIGN/CD209a marks the cells. PMID: 21029863
    17. utilized by lymph node medullar dendritic cells to capture influenza virus and promote humoral immunity PMID: 20305659
    18. Data show that SIGN-R1/TLR4(-/-) mice displayed reduced susceptibility to experimental colitis relative to severity of disease observed in wild-type or TLR4(-/-) mice. PMID: 20130211
    19. SIGN-R1 has also been demonstrated to bind sialylated antibody and mediate its activity to suppress autoimmunity PMID: 20054124
    20. DC-SIGN-specific mAb are channeled into the MHC class II presentation pathway PMID: 12456590
    21. Function of DC-SIGN as an antigen-capturing receptor of HIV-1. PMID: 15795245
    22. DC-SIGN is coordinately expressed upon classical and alternative macrophage activation and during dendritic cell maturation. PMID: 16051608
    23. CEACAM1, the major carrier of Lex residues in human granulocytes, is specifically recognized by DC-SIGN via Lex residues mediating the internalization of CEACAM1 into immature DCs PMID: 16282604
    24. Neck domain and CRD feastures and lack of multimerization inhibit functional interaction with EBOV-GP, suggesting that mDC-SIGN is not an adequate model for pathogen interactions with hDC-SIGN. PMID: 16297949
    25. The transmembrane lectin SIGN-R1 therefore contributes to innate resistance by an unusual C3 activation pathway. PMID: 16615889
    26. mouse DC-SIGN homologue SIGNR3 makes a unique contribution to protection of the host against a pulmonary bacterial pathogen. PMID: 19770268

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  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein.
  • 组织特异性：
    Predominantly expressed in dendritic cells. Detected at very low levels in lung, spleen, lymph nodes and bone marrow.
  • 数据库链接：

    KEGG: mmu:170786

    STRING: 10090.ENSMUSP00000012847

    UniGene: Mm.32510