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  4. Recombinant Mouse CD59A glycoprotein (Cd59a)

Recombinant Mouse CD59A glycoprotein (Cd59a)

  • 货号：
    CSB-YP528785MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP528785MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP528785MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP528785MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP528785MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cd59a
  • Uniprot No.：
  • 别名：
    Cd59a; Cd59CD59A glycoprotein; MAC-inhibitory protein; MAC-IP; Membrane attack complex inhibition factor; MACIF; Protectin; CD antigen CD59
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-96
  • 氨基酸序列
    LTCYHCF QPVVSSCNMN STCSPDQDSC LYAVAGMQVY QRCWKQSDCH GEIIMDQLEE TKLKFRCCQF NLCNKS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore.
  • 基因功能参考文献：
    1. Data (including data from studies using knockout mice) suggest that CD59a, CD59b, and ApoE are involved in development of diabetes-induced atherosclerosis; here, deficiency of CD59a/CD59b (in ApoE deficient mice) accelerates development of atherosclerosis in mice with type 1 diabetes. (CD59a = CD59a antigen; CD59b = CD59b antigen; ApoE = apolipoprotein E) PMID: 27729184
    2. Varicella-zoster virus infection upregulates host CD59 expression in a tissue-specific manner. PMID: 26891237
    3. This study support a role of Cd59a in controlling the innate immune status of the RPE-choroidal complex and emphasizes the particular vulnerability of this ocular compartment to the dysregulation of alternative complement pathway during aging PMID: 26234657
    4. results implicate CD59 as an important modulator of the immune response in NMO, and provide a novel animal model of NMO that closely recapitulates human NMO pathology. PMID: 24698947
    5. Soluble forms of CD59 (sCD59) have been investigated in mouse laser-induced choroidal neovascularization, a model for "wet" age related macular degeneration. PMID: 24664728
    6. both CD59 and C-PC could inhibit the progress of atherosclerosis, and the anti-atherosclerotic effects of C-PC might be fulfilled by promoting CD59 expression, preventing smooth muscle cell proliferation and the apoptosis of endothelial cells PMID: 24319687
    7. CD59a inhibits systemic autoimmunity in MRL/lpr mice through a complement-independent mechanism. PMID: 23109726
    8. While the connection between CFH deficiency and failure to upregulate CD59a remains unknown, these results suggest that expression of CD59 is tissue-specific and that neuroretinal regulation depends on CFH. PMID: 22918646
    9. Actively immunized experimental autoimmune myasthenia gravis mice deficient in either CD55 or CD59 showed significant differences in adaptive immune responses and worsened disease outcome associated with increased levels of serum cytokines, modified production of acetylcholine receptor antibodies, and more complement deposition at the neuromuscular junction. PMID: 22325826
    10. HBx can up-regulate CD59 and Crry expression in podocytes through activating the P38 pathway. PMID: 21215189
    11. CD59 has a role in growth of the choroidal neovascular complex in mice PMID: 20736175
    12. This study that CD59a protects against ischemic brain damage, but depending on the gender and the stroke model used. PMID: 20202211
    13. Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice. PMID: 20212283
    14. Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59b. PMID: 11471050
    15. Results of studies of autoantibody-mediated nephritis in CD59a knockout mice show that the activity of CD59 becomes clearly apparent in the absence of decay-accelerating factor, and thus the activities of both regulators are essential. PMID: 14764738
    16. CD59 acts synergistically with CD55 to inhibit complement-mediated renal ischemia-reperfusion injury. PMID: 15004194
    17. CD59a deficiency exacerbates ischemia-reperfusion injury in mice PMID: 15331407
    18. CD59a is the physiologically relevant regulator of membrane attack complex assembly in the majority of mouse tissues. PMID: 15356114
    19. Deletion of the gene encoding CD59a in mice increases disease severity in a murine model of rheumatoid arthritis. PMID: 15457473
    20. Reported the mapping of promoter regions of both mouse Cd59a and Cd59b genes and identified that each Cd59 gene expresses two different tissue-specific transcripts that differ at their 5'ends. PMID: 16541098
    21. CD59a plays a crucial role in regulating complement activation and MAC formation essential for the release of growth factors that drive the development of laser-induced choroidal neovascularization in mice PMID: 17237428
    22. Disease expression in CD59-deficient mice was no different than wild-type controls. DAF- and DAF/CD59-deficient mice also had increased monocyte chemoattractant protein-1 mRNA expression and glomerular infiltration with CD45(+) leukocytes. PMID: 17259999
    23. up-regulation of CD59 via ERK5/KLF2 activation leads to endothelial resistance to complement-mediated injury and protects from atherogenesis in regions of laminar shear stress PMID: 18362151
    24. Report accelerated atherosclerosis in low-density lipoprotein receptor-deficient mice lacking the membrane-bound complement regulator CD59. PMID: 18617646
    25. Total abrogation of mCd59 function in mCd59ab(-/-) mice results in complement-mediated hemolytic anemia that is rescued by the deficiency of C3 in compound mCd59ab(-/-)/C3(-/-) mice. PMID: 19051264
    26. Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex. PMID: 19131645
    27. There is an important role of CD59 in mediating protection from secondary neuronal cell death, and it further underscores the key role of the terminal complement pathway in the pathophysiology of traumatic brain injury. PMID: 19133139
    28. Data show that resolvin E1 and protectin D1 mimic the insulin-sensitizing and antisteatotic effects of omega-3-PUFAs and induce adiponectin expression to a similar extent to that of rosiglitazone. PMID: 19211925
    29. mCd59ab(-/-) platelets are sensitive to complement-mediated activation and provide evidence for possible in vivo platelet activation in mCd59ab(-/-) mice. PMID: 19229985
    30. Deficiency of the complement regulator CD59a exacerbates Wallerian degeneration. PMID: 19246097
    31. Crry and CD59 are critical in protecting Treg cells from complement mediated injuries PMID: 19281793
    32. Hepatitis B virus can sensitize hepatocytes to complement-dependent cytotoxicity through downregulating CD59, which may lead to the activation of complement system and cause liver inflammation. PMID: 19804910

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 组织特异性：
    Expressed in all tissues examined (liver, kidney, spleen, thymus, brain and heart). Low levels in thymus. Also expressed in mononuclear cells, erythrocytes and platelets. Barely detected in neutrophils.
  • 数据库链接：

    KEGG: mmu:12509

    STRING: 10090.ENSMUSP00000048041

    UniGene: Mm.247265