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  4. Recombinant Mouse COUP transcription factor 1 (Nr2f1)

Recombinant Mouse COUP transcription factor 1 (Nr2f1)

  • 货号：
    CSB-YP730643MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP730643MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP730643MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP730643MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP730643MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Nr2f1; Erbal3; Tfcoup1COUP transcription factor 1; COUP-TF1; COUP transcription factor I; COUP-TF I; Nuclear receptor subfamily 2 group F member 1; V-erbA-related protein 3; EAR-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-422
  • 氨基酸序列
    MAMVVSSWRD PQDDVAGGNP GGPNPAAQAA RGGGGGAGEQ QQAGSGAPHT PQTPGQPGAP ATPGTQGDKG QGPPGSGQSQ QHIECVVCGD KSSGKHYGQF TCEGCKSFFK RSVRRNLTYT CRANRNCPID QHHRNQCQYC RLKKCLKVGM RREAVQRGRM PPTQPNPGQY ALTNGDPLNG HCYLSGYISL LLRAEPYPTS RYGSQCMQPN NIMGIENICE LAARLLFSAV EWARNIPFFP DLQITDQVSL LRLTWSELFV LNAAQCSMPL HVAPLLAAAG LHASPMSADR VVAFMDHIRI FQEQVEKLKA LHVDSAEYSC LKAIVLFTSD ACGLSDAAHI ESLQEKSQCA LEEYVRSQYP NQPSRFGKLL LRLPSLRTVS SSVIEQLFFV RLVGKTPIET LIRDMLLSGS SFNWPYMSIQ CS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG.
  • 基因功能参考文献：
    1. COUP-TFI expression is required for functional organization of the hippocampal septo-temporal longitudinal axis PMID: 26813976
    2. These data identify silencer elements of the Nr2f1-A830082K12Rik gene pair as new candidate loci for Waardenburg syndrome type 4. PMID: 27585883
    3. Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons PMID: 28694260
    4. Transcription factors COUP-TFI and COUP-TFII are required for the production of granule cells in the mouse olfactory bulb. PMID: 25922524
    5. Findings provide evidence that Sp8 and another transcription factor, COUP-TF1, mutually repress each other's cortical neuroepithelial expression along the anterior-posterior and dorsoventral axes PMID: 23307639
    6. a novel tissue-dependent coregulatory network for NR2F1, miR-140, and Klf9 in the inner ear PMID: 24349493
    7. odour deprivation, which is known to downregulate tyrosine hydroxylase expression in the olfactory bulb, also downregulates COUP-TFI in dopaminergic cells, indicating a correlation between tyrosine hydroxylase- and COUP-TFI-activity-dependent action. PMID: 24227652
    8. CoupTFI collaborates with retinoic acid signaling to regulate both cortical ventricular zone progenitor cell behavior and cortical neurogenesis PMID: 23472160
    9. COUP-TFI and related NRs such as the COUPTFs and PNR can selectively associate with the developmental corepressor BCL11A via a conserved motif F/YSXXLXXL/Y within the RID1 and RID2 domains. The interaction with BCL11A facilitates COUP-TFII-mediated repression of the RARb2 gene. PMID: 23975195
    10. Our data suggest that the non-protein coding locus Mcs1a regulates Nr2f1, which is a candidate modifier of differentiation, proliferation, and mammary cancer risk. PMID: 23785296
    11. study extends the pool of recognized putative AR targets and identifies a negatively regulated target of AR - COUP-TF1 - which could possibly play a role in human prostate cancer PMID: 23056316
    12. Exogenous expression of COUP-TFI in AS cells, in a dose-dependent fashion, leads to growth inhibition. PMID: 23018522
    13. LHbeta promoter activity is further regulated by the orphan nuclear receptors, chicken ovalbumin upstream promoter-transcription factors (COUP-TFI and COUP-TFII). PMID: 20797425
    14. COUP-TFI controls the delicate balance between medial ganglionic eminence and caudal ganglionic eminence derived cortical interneurons by regulating intermediate progenitor divisions PMID: 21430164
    15. This study demonstrated that kallistatin expression is repressed by triiodothyronine and modulated by the orphan nuclear receptor, chicken ovalbumin upstream promoter transcription factor 1 (COUP-TF1). PMID: 21266512
    16. COUP-TFI exerts critical areal and temporal control over the precise differentiation of CSMN during corticogenesis, thereby enabling the area-specific functional features of motor and sensory areas to arise. PMID: 20133588
    17. Transcriptional and posttranscriptional mechanisms involving NR2F1 and IRE1beta ensure low microsomal triglyceride transfer protein expression in undifferentiated intestinal cells and avoid apolipoprotein B lipoprotein biosynthesis. PMID: 20007910
    18. Novel and distinct cell-intrinsic mechanisms mediated by COUP-TF genes to direct the specification and differentiation of progenitor cells; COUP-TFs are crucial for dorsalization of the eye. PMID: 20147377
    19. we found that COUP-TFI and -TFII play roles in amacrine cell differentiation, and COUP-TFgamma has distinct expression pattern and roles during retinal development. PMID: 19766631
    20. Results suggest COUP-TFI is an important regulator of oligodendrocyte differentiation. PMID: 14738874
    21. analysis of COUP-TFI and COUP-TFII expression during development and functional maturation of the mouse inner ear PMID: 15907456
    22. In the marginal zone (MZ) of the cortex , the nuclear receptor COUP-TFI is localized in calbindin-positive cells and not in reelin-positive cells and suggested represses differentiation of Cajal-Retzius cells. PMID: 16144621
    23. Results show that COUP-TFI is required for proper axonal growth and guidance of all major forebrain commissures. PMID: 17021036
    24. COUP-TF1 is an important signaling molecule during vitamin A (Rol)-mediated very early stage of embryonic development. PMID: 18177425

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Nuclear hormone receptor family, NR2 subfamily
  • 数据库链接：

    KEGG: mmu:13865

    STRING: 10090.ENSMUSP00000089036

    UniGene: Mm.439653