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  4. Recombinant Mouse Cadherin-13 (Cdh13)

Recombinant Mouse Cadherin-13 (Cdh13)

  • 中文名称：
    Recombinant Mouse Cadherin-13(Cdh13),Yeast
  • 货号：
    CSB-YP895275MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Cadherin-13(Cdh13),Yeast
  • 货号：
    CSB-EP895275MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Cadherin-13(Cdh13),Yeast
  • 货号：
    CSB-EP895275MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Cadherin-13(Cdh13),Yeast
  • 货号：
    CSB-BP895275MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Cadherin-13(Cdh13),Yeast
  • 货号：
    CSB-MP895275MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cdh13
  • Uniprot No.：
  • 别名：
    Cdh13; Cadherin-13; Heart cadherin; H-cadherin; Truncated cadherin; T-cad; T-cadherin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    139-693
  • 氨基酸序列
    SI VVSPILIPEN QRQPFPRDVG KVVDSDRPEG SKFRLTGKGV DQDPKGTFRI NENTGSVSVT RTLDRETIAT YQLYVETTDA SGKTLEGPVP LEVIVIDQND NRPIFREGPY IGHVMEGSPT GTTVMRMTAF DADDPATDNA LLRYNIRQQT PDKPSPNMFY IDPEKGDIVT VVSPALLDRE TLENPKYELI IEAQDMAGLD VGLTGTATAT IVIDDKNDHS PKFTKKEFQA TVEEGAVGVI VNLTVEDKDD PTTGAWRAAY TIINGNPGQS FEIHTNPQTN EGMLSVVKPL DYEISAFHTL LIKVENEDPL VPDVSYGPSS TATVHITVLD VNEGPVFYPD PMMVTKQENI SVGSVLLTVN ATDPDSLQHQ TIRYSIYKDP AGWLSINPIN GTVDTTAVLD RESPFVHNSV YTALFLAIDS GNPPATGTGT LLITLEDIND NAPVIYPTVA EVCDDARNLS VVILGASDKD LHPNTDPFKF EIHKQTVPDK VWKISKINNT HALVSLLQNL NKANYNLPIM VTDSGKPPMT NITDLRVQVC SCKNSKVDCN GAG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
  • 基因功能参考文献：
    1. Findings show that Cdh13 is critical for inhibitory function of Golgi cells, and that GlyT2::Cre-mediated deletion of Cdh13 in non-executive centers of the brain, such as the cerebellum, may contribute to cognitive and social behavioral deficits linked to neurological disorders. PMID: 29446202
    2. Studies findings identified a novel protective role for cadherin-13 in cortical neuron development. PMID: 28386779
    3. using rat and murine aortic smooth muscle cells as experimental models, we surveyed the ability of T-cadherin to regulate autophagy in SMCs during serum-starvation stress. Overall our findings have identified T-cadherin as a novel positive regulator of autophagy and survival in smooth muscle cells PMID: 28392425
    4. T-cadherin was essential for accumulation of adiponectin in the neointima and atherosclerotic plaque lesions, and the adiponectin-T-cadherin association protected against vascular injury. PMID: 28062540
    5. T-cadherin deficiency causes endothelial dysfunction in Type II Diabetes Mellitus. PMID: 28103886
    6. a unique key feature of the T-cad prodomain is its involvement in binding of the T-cad repeats 1 and 2 to adiponectin; adiponectin positively regulates T-cad abundance PMID: 28325833
    7. CDH13 is a negative regulator of inhibitory synapses in the hippocampus, and provide insights into how CDH13 dysfunction may contribute to the excitatory/inhibitory imbalance observed in Attention Deficit Disorder with Hyperactivity. PMID: 26460479
    8. These data show that both circulating and tissue-bound Adipo levels are dependent on Tcad and, in reverse, regulate tissue Tcad levels through a positive feedback loop. PMID: 25514086
    9. These data highlight a previously unrecognized role for T-cadherin in limb revascularization and show that it is essential for mediating the vascular actions of adiponectin. PMID: 23824191
    10. T-cad does not mediate the protective effects of adiponectin in allergic airways responses in mice PMID: 22815927
    11. T-cadherin is a component of insulin granules, suggesting that it contributes to the regulation of insulin secretion independently of direct interactions with adiponectin. PMID: 21975561
    12. T-cad can exert pleiotropic effects on squamous cell carcinoma progression; up- or down-regulation of T-cad can promote tumour expansion in vivo. PMID: 21766307
    13. T-cadherin protects from stress-induced pathological cardiac remodeling by binding APN and activating its cardioprotective functions. PMID: 21041950
    14. hyperexpression of T-cadherin in the B16F10 cells suppresses the proliferation of these cells in vitro and the growth of the tumor masses formed by melanoma cells on the chorioallantoic membrane and their neovascularization PMID: 20873143
    15. Expression of T-cadherin in Basal keratinocytes of skin. PMID: 12060406
    16. T-cadherin has a role in growth regulation involving p21(CIP1/WAF1) expression and G2 arrest PMID: 12509455
    17. Because T-cadherin is a glycosylphosphatidylinositol-anchored extracellular protein, it may act as a coreceptor for an as-yet-unidentified signaling receptor through which adiponectin transmits metabolic signals. PMID: 15210937
    18. T-cadherin is novel modulator of angiogenesis. Molecule can be exploited as target for modulation of therapeutic angiogenesis, as well as for prevention of pathological conditions associated with abnormal neovascularization. PMID: 16873731
    19. T-cadherin suppresses angiogensis in vivo by inhibiting migration of endothelial cells. PMID: 17486418
    20. the vascular T-cadherin-adiponectin association may contribute to the molecular cross-talk between tumor cells and the stromal compartment in breast cancer PMID: 18316604
    21. both cellular and acellular presentation of T-cadherin can be used to modulate the hepatocyte phenotype in vitro for tissue engineering applications. PMID: 18635739

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 数据库链接：

    KEGG: mmu:12554

    STRING: 10090.ENSMUSP00000113527

    UniGene: Mm.334841