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  4. Recombinant Mouse Calcium signal-modulating cyclophilin ligand (Camlg), partial

Recombinant Mouse Calcium signal-modulating cyclophilin ligand (Camlg), partial

  • 中文名称：
    Recombinant Mouse Calcium signal-modulating cyclophilin ligand(Camlg),partial,Yeast
  • 货号：
    CSB-YP004475MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Calcium signal-modulating cyclophilin ligand(Camlg),partial,Yeast
  • 货号：
    CSB-EP004475MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Calcium signal-modulating cyclophilin ligand(Camlg),partial,Yeast
  • 货号：
    CSB-EP004475MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Calcium signal-modulating cyclophilin ligand(Camlg),partial,Yeast
  • 货号：
    CSB-BP004475MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Calcium signal-modulating cyclophilin ligand(Camlg),partial,Yeast
  • 货号：
    CSB-MP004475MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Camlg
  • Uniprot No.：
  • 别名：
    Camlg; CamlCalcium signal-modulating cyclophilin ligand; CAML
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.
  • 基因功能参考文献：
    1. this study identified a novel role for B cell-specific, BAFF-dependent transmembrane activator and CAML interactor signals in atherosclerosis pathogenesis PMID: 27837104
    2. supports T cell survival and cell division downstream of T cell activation PMID: 26561552
    3. Deletion of calcium-modulating cyclophilin ligand causes deafness in mouse model. PMID: 22170629
    4. Conditional deletion of CAML in CD19-Cre transgenic mice reduced follicular B cell numbers & increased rates of homeostatic proliferation. They had increased cellular turnover & normal proliferative ability. PMID: 22351938
    5. Loss of CAMLG protein failed to undergo normal T-cell development and exhibited dramatically increased rates of apoptosis. PMID: 20300112
    6. results implicate Tmub1 in the regulation of locomotor activity and wakefulness and suggest that Tmub1 binds to and functions together with CAMLG PMID: 20582322
    7. These data implicate calcium-modulating cyclophilin ligand in epidermal growth factor (EGF) receptor signaling and suggest that it may play a role in receptor recycling during long-term proliferative responses to EGF. PMID: 12919676
    8. CAML as an essential mediator of T cell survival during thymopoiesis and its loss deregulates lymphocyte specific protein tyrosine kinase p56(p56Lck) signaling. PMID: 16111633
    9. specific role of CAML in functional expression and endocytic recycling of postsynaptic GABA(A) receptors PMID: 18424167
    10. our data identify CAML as a novel chromosomal instability gene and suggest that CAML protein acts as a key regulator of mitotic spindle function and a modulator of SAC maintenance. PMID: 19229138

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 数据库链接：

    KEGG: mmu:12328

    STRING: 10090.ENSMUSP00000021963

    UniGene: Mm.2313