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  4. Recombinant Mouse Carbonic anhydrase 6 (Ca6)

Recombinant Mouse Carbonic anhydrase 6 (Ca6)

  • 中文名称：
    Recombinant Mouse Carbonic anhydrase 6(Ca6),Yeast
  • 货号：
    CSB-YP004377MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Carbonic anhydrase 6(Ca6),Yeast
  • 货号：
    CSB-EP004377MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Carbonic anhydrase 6(Ca6),Yeast
  • 货号：
    CSB-EP004377MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Carbonic anhydrase 6(Ca6),Yeast
  • 货号：
    CSB-BP004377MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Carbonic anhydrase 6(Ca6),Yeast
  • 货号：
    CSB-MP004377MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ca6
  • Uniprot No.：
  • 别名：
    Ca6; Car6Carbonic anhydrase 6; EC 4.2.1.1; Carbonate dehydratase VI; Carbonic anhydrase VI; CA-VI; Salivary carbonic anhydrase; Secreted carbonic anhydrase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    18-317
  • 氨基酸序列
    HSD WSYSGDDGVG ESQWSEQYPS CGGERQSPID VKTEEVMFNP SLKPLSLVNY EKENLEFTMT NNGHTVSIDL PPSMYLETSD GTEFISKAFH FHWGGRDWEL SGSEHTIDGI RSIMEAHFVH FNKEYGTYEN AKDQKNGLAV LAVLFKIDEY AENTYYSDII SALKNIEKPG ETTTLKDTTI RNLLPKDVHH YYTYPGSLTT PPCTENVQWF VLRDKVTLSK AQVVTIENSV MDHNNNTIQN GYRSTQPNNH RVVEANFLNV QDMYSSYHLY LKNMQKEILQ PKKQKKTKKN RHFWSRK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Reversible hydration of carbon dioxide. Its role in saliva is unknown.
  • 基因功能参考文献：
    1. the nuclear localized CA-VI B selectively promotes IL-12 expression by interaction with protein arginine N-methyltransferase 5 (PRMT5), which reduces symmetric dimethylation of histone H3 arginine 8 modification (H3R8me2s) at Il12 promoters to facilitate chromatin accessibility, selectively enhancing c-Rel binding to the Il12b promoter. PMID: 28739930
    2. he altered biological processes included antigen transport by M-cells, potassium transport, muscle contraction, and thyroid hormone synthesis. Immunohistochemical staining confirmed the absence of CA VI in the submandibular gland of Car6 (-/-) mice PMID: 27209317
    3. knockout mouse model confirms that CA VI is involved in bitter taste perception. CA VI may be one of the factors which contribute to avoidance of bitter, potentially harmful, substances. PMID: 25134447
    4. The generation of Car6 (-/-) mice and examination of the effects of CAVI deficiency on gene transcription have revealed several affected clusters of biological processes, which implicate CAVI in catabolic processes and the immune system response. PMID: 20835760
    5. expression of Car6 significantly decreased in enamel organs from Mmp20(-/-) mice. A feedback mechanism regulates ion-responsive gene expression during enamel development. PMID: 20929715

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Alpha-carbonic anhydrase family
  • 组织特异性：
    Major constituent of saliva.
  • 数据库链接：

    KEGG: mmu:12353

    STRING: 10090.ENSMUSP00000030817

    UniGene: Mm.232523