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  4. Recombinant Mouse Carboxylesterase 1C (Ces1c), partial

Recombinant Mouse Carboxylesterase 1C (Ces1c), partial

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  • 中文名称：
    Recombinant Mouse Carboxylesterase 1C(Ces1c),partial
  • 货号：
    CSB-YP338557MO
  • 规格：
    ￥2208
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP338557MO could indicate that this peptide derived from Yeast-expressed Mus musculus (Mouse) Ces1c.
    • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP338557MO could indicate that this peptide derived from Yeast-expressed Mus musculus (Mouse) Ces1c.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Carboxylesterase 1C; Ces N; Ces1c; Ee 1; Ee 4; Ee1; Es N; Es1; Es4; EsN; EST1C_MOUSE; Esterase 1; Liver carboxylesterase N; Lung surfactant convertase; PES-N; PESN
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 来源：
    Yeast
  • 分子量：
    60.6kDa
  • 表达区域：
    19-550aa
  • 氨基酸序列
    HSLLPPVVDTTQGKVLGKYISLEGFEQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNATSYPPMCSQDAGWAKILSDMFSTEKEILPLKISEDCLYLNIYSPADLTKSSQLPVMVWIHGGGLVIGGASPYNGLALSAHENVVVVTIQYRLGIWGLFSTGDEHSPGNWAHLDQLAALRWVQDNIANFGGNPDSVTIFGESSGGISVSVLVLSPLGKDLFHRAISESGVVINTNVGKKNIQAVNEIIATLSQCNDTSSAAMVQCLRQKTESELLEISGKLVQYNISLSTMIDGVVLPKAPEEILAEKSFNTVPYIVGFNKQEFGWIIPMMLQNLLPEGKMNEETASLLLRRFHSELNISESMIPAVIEQYLRGVDDPAKKSELILDMFGDIFFGIPAVLLSRSLRDAGVSTYMYEFRYRPSFVSDKRPQTVEGDHGDEIFFVFGAPLLKEGASEEETNLSKMVMKFWANFARNGNPNGEGLPHWPEYDEQEGYLQIGATTQQAQRLKAEEVAFWTELLAKNPPETDPTEH
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：
        小鼠羧酸酯酶1C（Ces1c）是一种重要的丝氨酸水解酶家族成员，主要分布于人体肝脏中，肠道组织中几乎没有。在小鼠中，Ces1c的缺失会影响药物和脂质代谢及稳态。值得注意的是，虽然Ces1c在小鼠中起着重要的作用，但在某些情况下，如药物开发中，Ces1c的缺失可能会带来一些问题。例如，Ces1c的缺失可能会导致药物在小鼠体内的代谢和稳态受到影响。因此，在进行药物开发时，需要考虑到Ces1c的作用，以便更好地理解和利用其特性。
        j9九游会登录入口首页生物的小鼠羧酸酯酶1C（Ces1c）重组蛋白，由酵母表达系统表达，表达区域为1-441aa，具备高纯度高稳定性等特点，助您进行相关科学研究。
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant.
  • 基因功能参考文献：
    1. Phospho-non-steroidal anti-inflammatory drugs hydrolysis in wild-type mouse plasma was 6-530-fold higher than that in the plasma of Ces1c-/- mice. PMID: 25392229
    2. Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels PMID: 25285996
    3. These results identify and characterize ES1 as a novel transcriptional regulator of GHR gene expression. PMID: 21659478
  • 亚细胞定位：
    Endoplasmic reticulum lumen. Note=Microsomal membrane, lumen of endoplasmic reticulum.
  • 蛋白家族：
    Type-B carboxylesterase/lipase family
  • 组织特异性：
    Expressed in lung, kidney and liver.
  • 数据库链接：

    KEGG: mmu:13884

    STRING: 10090.ENSMUSP00000034189

    UniGene: Mm.88078