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  4. Recombinant Mouse Carboxypeptidase B2 (Cpb2)

Recombinant Mouse Carboxypeptidase B2 (Cpb2)

  • 货号：
    CSB-YP864310MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP864310MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP864310MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP864310MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP864310MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cpb2; TafiCarboxypeptidase B2; EC 3.4.17.20; Carboxypeptidase R; CPR; Carboxypeptidase U; CPU; Thrombin-activable fibrinolysis inhibitor; TAFI
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    114-422
  • 氨基酸序列
    ASASYYE QYHSLNEIYS WIEVITEQHP DMLQKIYIGS SFEKYPLYVL KVSGKEQRIK NAIWIDCGIH AREWISPAFC LWFIGYVTQF HGKENLYTRL LRHVDFYIMP VMNVDGYDYT WKKNRMWRKN RSAHKNNRCV GTDLNRNFAS KHWCEKGASS SSCSETYCGL YPESEPEVKA VADFLRRNID HIKAYISMHS YSQQILFPYS YNRSKSKDHE ELSLVASEAV RAIESINKNT RYTHGSGSES LYLAPGGSDD WIYDLGIKYS FTIELRDTGR YGFLLPERYI KPTCAEALAA ISKIVWHVIR NT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
  • 基因功能参考文献：
    1. Results indicate that TAFIa could be a novel biomarker and realistic therapeutic target of chronic thromboembolic pulmonary hypertension. PMID: 28289017
    2. Cpb2-deficient mice had decreased pneumococcal meningitis mortality and attenuated cytokine levels and bacterial outgrowth in the systemic compartment but not in the brain compartment, as compared with wild-type mice. PMID: 26340319
    3. Carboxypeptidase B2 deficiency reveals that complement C3a limits infection and C5a exacerbates infection in a murine polymicrobial sepsis model. PMID: 25851247
    4. Combination of TAFI-I and a low dose of rtPA was not as effective as the standard dose of rtPA in treating thromboembolic stroke, while TAFI inhibition alone was not effective at all. PMID: 25401979
    5. In an induced osteoarthritis model, CPB2 knockout mice developed dramatically greater cartilage damage than did wild-type mice, had a greater number of osteophytes, and a greater degree of synovitis. PMID: 24449579
    6. TAFI deficiency results in accelerated fibrogenesis and increased liver damage in murine models of chronic and acute liver disease, which may be related to increased inflammation. PMID: 23467679
    7. The unique NFkappaB site in the mouse CPB2 promoter is functional and mediates the upregulation of mouse CPB2 expression by TNFalpha. PMID: 22217421
    8. These findings suggest that plasma carboxypeptidase B plays a critical role in dampening local, C5a-mediated inflammation and represents a molecular link between inflammation and coagulation in autoimmune arthritis. PMID: 21804193
    9. In another mouse experiment, animals infected with isogenic Bacillus anthracis inhA deletion mutants restored TAFI levels, while the levels in the parent strain decreased. PMID: 21395696
    10. Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica. PMID: 21724997
    11. Apo-E deficiency alone is not associated with tumors but a lack of TAFI appears to make the mice permissive for tumor formation in ApoE mice PMID: 20723031
    12. Study establishes the role of carboxypeptidase U in experimental abdominal aortic aneurysm disease, indicating that CPB has a broad anti-inflammatory role in vivo. PMID: 20431069
    13. TAFI-deficient monocrotaline-treated mice had less pulmonary hypertension, vascular remodeling and reduced levels of cytokines possibly as a result of reduced coagulation activation. PMID: 20088932
    14. role of pCPB as a modulator of the pivotal functions of plasminogen in fibrinolysis and cell migration in vivo. PMID: 12417566
    15. there is a functional glucocorticoid response element (GRE) in the TAFI promoter which is capable of binding the glucocorticoid receptor PMID: 12645517
    16. TAFI appears to be important for appropriate organization of the healing process PMID: 14521589
    17. In all tumor models TAFI deficiency did not affect the formation and growth of primary and metastasized tumors. PMID: 15099284
    18. thrombin-activable fibrinolysis inhibitor expression is enhanced by insulin through the PI3 kinase/Akt pathway PMID: 15647842
    19. The anti-fibrinolytic activity of TAFI promotes lung fibrosis by hindering the rate at which fibrin is degraded. PMID: 16565485
    20. beneficial effect of E229K thrombin is due to the direct inhibition of complement C5a by procarboxypeptidase B PMID: 17105819
    21. data provide direct evidence for the role of TAFIa in vena cava thrombosis without the addition of exogenous thrombolytic in mice PMID: 17111204
    22. increased renal activity of plasmin in TAFI-deficient mice causes increased renal interstitial fibrosis in obstructive nephropathy. PMID: 17988229
    23. Suggest that TAFI-mediated inhibition of plasmin generation plays a role in the pathogenesis of glomerulonephritis. PMID: 18612543

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase M14 family
  • 组织特异性：
    Plasma; synthesized in the liver.
  • 数据库链接：

    KEGG: mmu:56373

    STRING: 10090.ENSMUSP00000022576

    UniGene: Mm.24242