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  4. Recombinant Mouse Cartilage acidic protein 1 (Crtac1)

Recombinant Mouse Cartilage acidic protein 1 (Crtac1)

  • 货号：
    CSB-YP005997MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP005997MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP005997MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP005997MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP005997MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Crtac1
  • Uniprot No.：
  • 别名：
    Crtac1; Aspic1; Cep68Cartilage acidic protein 1; 68 kDa chondrocyte-expressed protein; CEP-68; ASPIC; Protein CRTAC1-B
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    29-646
  • 氨基酸序列
    SQ RAEPMFTAVT NSVLPPDYDS NPTQLNYGVA VTDVDHDGDF EIVVAGYTGP NLVLKYNRAQ NRLVNIAVDE RSSPYYALRD RQGNAIGVTA CDIDGDGREE IYFLNTNNAF SGVATYTDKL FKFRNNRWED ILSDDVNVAR GVASLFAGRS VACVDRTGSG RYSIYIANYA YGDVGPDALI EMDPEASDLS RGILALRDVA AEAGVSKYTA GRGVSVGPIL SSSASDIFCD NENGPNFLFH NQGNGTFVDT AASAGVDDPH QHGRGVALAD FNRDGKVDIV YGNWNGPHRL YLQMSAHGKV RFRDIASPKF STPSPVRTVI AADFDNDQEL EVFFNNIAYR SSSANRLFRV IRREHGDPLI EELNPGDALE PEGRGTGGVV TDFDGDGMLD LILSHGESMA QPLSVFRGNQ GFSNNWLRVV PRTRFGAFAR GAKVVLYTKK SGAHLRIIDG GSGYLCEMEP VAHFGLGRDE ASSVEVTWPD GKMVSRSVAS EEMNSVLEIL YPQDEDKLQN TAPLECGQGF SQQDNGHCMD TNECIQFPFV CPRDKPVCVN TYGSYRCRTN KRCNRGYEPN EDGTACVAQV AFLGGYSSAA FRLSEPLSQA SYLSLGLGLC LQLYAL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Genetic deletion of Crtac1 significantly inhibited cartilage degradation, osteophyte formation and gait abnormalities of post-traumatic OA in female, but not male, animals undergoing the destabilization of medial meniscus (DMM) surgery. PMID: 27415616
    2. These data suggest that LOTUS functions as a potent endogenous antagonist for NgR1 when bound by all four known NgR1 ligands. PMID: 25034269
    3. These findings suggest that the UA/EC region is a functional domain of LOTUS serving for an antagonistic action to NgR1. PMID: 22281491
    4. found CRTAC1-B(LOTUS)is key molecule for lateral olfactory tract(LOT)formation; NgR1 is LOTUS-binding protein;LOTUS suppressed Nogo-NgR1 binding and Nogo-induced growth cone collapse;suggest endogenous antagonism of NgR1 by LOTUS crucial for LOT formation PMID: 21817055
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 数据库链接：

    KEGG: mmu:72832

    STRING: 10090.ENSMUSP00000044858

    UniGene: Mm.313558