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  4. Recombinant Mouse Caspase-7 (Casp7)

Recombinant Mouse Caspase-7 (Casp7)

  • 货号：
    CSB-YP004552MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP004552MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP004552MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP004552MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP004552MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Casp7; Lice2; Mch3Caspase-7; CASP-7; EC 3.4.22.60; Apoptotic protease Mch-3; Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-23
  • 氨基酸序列
    TDDQDCAAE LEKVDSSSED GVD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Overexpression promotes programmed cell death. Cleaves phospholipid scramblase proteins XKR4, XKR8 and XKR9.
  • 基因功能参考文献：
    1. Caspase 7 has a nonapoptic function that participates in normal spermatogenesis, but also displays apoptotic function in spermatogenic dysfunction. PMID: 26643564
    2. Our study shows for the first time activated caspase-7 in hair follicles and mast cells and indicates its non-apoptotic roles in the skin. PMID: 26253163
    3. Optic nerve crush activated caspase-7 in retinal ganglion cells followed by cell death. Knockout of caspase-7 partially and significantly protected against ON injury-induced RGC loss. PMID: 26306916
    4. genetic loss of caspase-7 promotes solar-simulated light-induced skin carcinogenesis by blocking caspase-7-mediated cleavage of keratin-17. PMID: 26271098
    5. In vitro, with application of specific inhibitors and siRNA, AND-induced apoptosis was proven through ROS-ERK-P53-caspase 7-PARP signaling pathway PMID: 25162007
    6. The scotopic electroretinography demonstrated that the ablation of the CASP7 in T17M RHO retina leads to significant preservation of the function of photoreceptors compared to controls. PMID: 24664731
    7. Data suggest that caspase-7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices. PMID: 23713787
    8. The results indicate a non-essential apoptotic role of caspase-7 in the PEK apoptosis but suggest also possible non-apoptotic functions for caspase-7 in tooth development. PMID: 22858065
    9. host activation of caspase-7 in response to pore formation represents an adaptive mechanism by which host cells can protect membrane integrity during Listeria monocytogenes infection PMID: 22807671
    10. An apoptosis-independent regulatory role for caspase 7-mediated PARP1 cleavage in proinflammatory gene expression is discussed. PMID: 22464733
    11. Our findings demonstrate for the first time a strong correlation between caspase-7 activity, normal brain development, and apoptotic DNA fragmentation in Casp3-/- mice. PMID: 15525783
    12. Our results show that in contrast to dermal fibroblasts and cortical neurons, sympathetic neurons express no detectable levels of caspase-7. PMID: 16932756
    13. proteolytic processing of ataxin-7 by caspase-7 may contribute to SCA7 disease pathogenesis PMID: 17646170
    14. Caspase-7 was activated in the splenocytes of LPS-injected mice. CASP-7-deficient mice resist LPS-induced lymphocyte apoptosis & are protected from LPS-induced lethality independently of the excessive production of serum cytokines. PMID: 19168786
    15. results reveal a new mechanism for caspase-7 activation downstream of the Nlrc4 inflammasome and present a novel biological role for caspase-7 in host defense against Legionella pneumophila PMID: 19343209
    16. In mid-gestational wounds, activation of apoptotic pathways may be mediated through effector caspase 7 signals with inactivation of PARP. PMID: 19555972

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase C14A family
  • 组织特异性：
    Highly expressed in heart, lung, liver and kidney. Low levels in spleen, skeletal muscle and testis. No expression in the brain.
  • 数据库链接：

    KEGG: mmu:12369

    STRING: 10090.ENSMUSP00000026062

    UniGene: Mm.35687