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  4. Recombinant Mouse Caveolin-1 (Cav1), partial

Recombinant Mouse Caveolin-1 (Cav1), partial

  • 货号：
    CSB-YP004571MO1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP004571MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP004571MO1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP004571MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP004571MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cav1; Cav; Caveolin-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation.
  • 基因功能参考文献：
    1. We developed a protocol to label B16F10 cells with AuNPs-PEG-TAT that permits subsequent tracking of cells in mice. CAV1 overexpression was found to increase retention and transendothelial migration of B16F10 cells in the lung. PMID: 29972676
    2. Cav-1 deletion is able to suppress High Fat Diet-induced oxidative stress and dyslipidemia in ApoE-/- mice. PMID: 29746866
    3. Transplantation of a denuded aorta into carotid artery leads to plaque formation. Caveolin-1 knockout leads to increased plaque formation. Additional knockout of eNOS in Cav1-/- aortae reduces plaque formation. PMID: 27915034
    4. the CAV1-/- mice were characterized by a low-grade systemic proinflammatory status, with a moderate increase in the IL-6, TNF-alpha, and IL-12p70 levels CAV1-/- circulating lymphocytes were more prone to cytokine production upon nonspecific stimulation than the wild-type lymphocytes PMID: 30246033
    5. data suggest that lung cancer cells escape oncogene-induced premature senescence through down-regulation of caveolin-1 expression to progress from premalignant lesions to cancer. PMID: 29247004
    6. This study defines ZNRF1 as a regulator of TLR4-induced inflammatory responses and reveals another mechanism for the regulation of TLR4 signalling through CAV1. PMID: 28593998
    7. Renal Cav1 promotes water and salt reabsorption via modulation of NCC function and regulation of vascular eNOS. PMID: 29323234
    8. Sirt1 preserves Cav1-dependent endothelial function by mitigating miR-204-mediated vascular endoplasmic reticulum stress. PMID: 28181559
    9. Cav1 is an important inhibitor of TGF-β1/Smad signaling in hepatic stellate cell activation and collagen production. PMID: 29891777
    10. the present study indicated that Cav-1-/- accelerated liver injury in a mouse model of liver fibrosis through enhancing oxidative stress, inflammatory response and fibrosis progression PMID: 29549726
    11. MURC binds to Cav1 and inhibits the association of Cav1 with the active form of Galpha13, resulting in the facilitated association of the active form of Galpha13 with p115RhoGEF. These results reveal that MURC has a function in the development of pulmonary hypertension through modulating Rho/ROCK signaling. PMID: 27546070
    12. The part of PKC regulation of CaV1.2 in the heart involves changes in channel's cellular fate. The mechanism of this PKC regulation appears to involve the C-terminus of alpha1C, possibly corroborating the previously proposed role of NT-CT interactions within alpha1C. PMID: 28901828
    13. Findings suggest that CAV1 might be involved in apoptosis and proliferation regulation in pancreatic beta cells. PMID: 29412792
    14. Caveolin1 is required for Th1 cell infiltration, but not tight junction remodeling at the Blood-Brain Barrier in autoimmune neuroinflammation PMID: 29166603
    15. Results suggest distinct functional roles for type 1 ryanodine receptor (RYR1) and Ca2+ channels-the 1,4-dihydropyridine receptor (Cav1.1) in skeletal primary and secondary myogenesis. PMID: 29543863
    16. genetic deletion of Cav-1 exacerbated and cavtratin administration inhibited choroidal and retinal neovascularization PMID: 28923916
    17. findings suggest that HMGB1 induces the transcytosis of albumin via RAGE-dependent Src phosphorylation and Cav-1 phosphorylation. These studies revealed a new mechanism of HMGB1-induced endothelial hyperpermeability. PMID: 27572515
    18. caveolin-1 (Cav-1) participates in intraocular pressure maintenance via modulation of aqueous humor drainage from the eye. PMID: 27841369
    19. DJ-1 has a role in glutamate uptake into astrocytes by regulating flotillin-1 and caveolin-1 expression PMID: 27346864
    20. These results suggest that the phosphorylated CAV1 functions to activate autophagy through binding to the BECN1/VPS34 complex under oxidative stress and to protect against ischemic damage. PMID: 28542134
    21. The effects of ouabain on contractility between WT and cav-1 KO mice were not significantly different. PMID: 27519543
    22. Nitric oxide promotes caveolin-1-mediated delivery of claudin-5 to the autophagosome for autophagy-lysosome-dependent degradation. PMID: 26515186
    23. Caveolin-1 phosphorylation on tyrosine 14 may have a role in augmenting melanoma metastasis but not tumorigenesis PMID: 27259249
    24. Caveolin-1 enhances internalization and degradation of ABCA1 by its association with ABCA1 PMID: 27579791
    25. cav-1 knockout mice exhibited higher levels of homeostatic model assessment of insulin resistance, cholesterol, and resistin and lower ratios of high- to low-density lipoprotein. cav-1 knockout mice displayed hypertriglyceridemia and higher mRNA levels for resistin, retinol binding protein 4, NADPH oxidase 4, and aldose reductase in liver and/or fat tissues. PMID: 27680666
    26. we conclude that Cav-1 could play a critical role in preventing nitrative stress-induced liver damage during hepatic ischemia-reperfusion injury PMID: 27021966
    27. These results point to intestinal epithelial cell CAV1 as a potential therapeutic target to lower circulating free fatty acids and LDL cholesterol. PMID: 28130355
    28. Cav-1 deficiency induces premature senescence via mitochondrial dysfunction and SIRT1 inactivation. PMID: 28514055
    29. Data show that phosphorylation of caveolin-1 on Tyr(14) in microglia induced the internalization of sodium-vitamin C cotransporter 2 (SVCT2). PMID: 28351945
    30. caveolin-1 maintains mitochondrial integrity and function when cells are challenged with free radicals by promoting the mitochondrial localization of m-AAA protease and its quality control functions. PMID: 27705926
    31. the PRNP octapeptide repeat domain was necessary to promote exosome secretion and to impair the formation of the CAV1-dependent ATG12-ATG5 cytoplasmic complex that drives autophagosome formation. PMID: 27629560
    32. results identify a role for Cav1 in membrane organization and beta2 integrin function in primary CD8 T cells. PMID: 28637901
    33. we have identified Cav1 as a regulator of the nanoscale organization of IgM-BCRs and IgD-BCRs in the plasma membrane of B cells. PMID: 28805811
    34. CAV1 serves as an important protective factor in the development of NAFLD by modulating lipid metabolism gene expression PMID: 28570612
    35. The findings of this study suggested an important role by which neuron-targeted Cav-1 regulates DISC1 neurobiology with implications for synaptic plasticity. PMID: 27832597
    36. CAV1 is an anti-lithogenic factor and that the CAV1(-/-) mice may offer a convenient CGD model to develop therapeutic interventions for this disease PMID: 26875794
    37. these findings indicated that the downregulation of GATA-6 effectively inhibited airway inflammation and reversed airway remodeling via Cav-1 PMID: 27289030
    38. Cav1, and presumably caveolae, in vascular smooth muscle and the endothelium plays a critical role in vascular remodeling and inflammation independent of blood pressure or cardiac hypertrophy regulation. PMID: 27895190
    39. Neuron-targeted overexpression of caveolin-1 in the adult and aged hippocampus enhances functional membrane/lipid rafts with corresponding roles in cell signaling and protein trafficking. PMID: 26592463
    40. Loss of cav-1 resulted in increased ECM protein expression in murine mammary glands and abnormal ductal architecture. PMID: 28187162
    41. Cavin-1 deficiency resulted in maladaptative autophagy that contributed to insulin resistance and altered adipocyte differentiation. PMID: 27144934
    42. Cav-1 gene silencing in lung fibroblasts is actively regulated by epigenetic mechanisms. PMID: 27560128
    43. Cav-1 knock-out mice showed experimental autoimmune encephalomyelitis resistance with decreased incidence and clinical symptoms. Cav-1 knock-out mice had alleviated encephalitogenic T cells trafficking into the CNS. PMID: 27170118
    44. CAV1 KO mice had elevated IOP and decreased outflow facility, CAV1 deficiency (and possibly the loss of CAV2) resulted in increased eNOS activity. PMID: 27228562
    45. Caveolin-1 was expressed in human FVMs and upregulated in the mouse eyes with PVR. Caveolin-1 in RPE cells prevents PVR by blocking EMT. PMID: 28114583
    46. The mechanism by which Cav-1 knockout promotes corneal regrowth is, at least partially, due to the inhibition of Kir4.1 which stimulates EGFR signaling. PMID: 27122158
    47. a novel mechanism and model in which CAV1 phosphorylation facilitates CAV1 scaffolding and GRK2-CAV1 interaction, thus clustering eNOS within a complex that inhibits eNOS activity, is reported. PMID: 28162981
    48. Cav-1 is a critical determinant of BBB permeability. PMID: 27012742
    49. This study demonstrates, for the first time, that Cav-1 is expressed in developing periodontal tissue and in vitro in periodontal-related cells PMID: 26686692
    50. In vitro caveolin-1 silencing decreased the chondrocyte-like cell microaggregate glycosaminoglycan (GAG) content PMID: 26939667

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  • 亚细胞定位：
    Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Golgi apparatus, trans-Golgi network.
  • 蛋白家族：
    Caveolin family
  • 组织特异性：
    Adipose tissue, lung, heart, skeletal muscle, stomach, small bowel, kidney, spleen and testis (at protein level).
  • 数据库链接：

    KEGG: mmu:12389

    STRING: 10090.ENSMUSP00000007799

    UniGene: Mm.28278