Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Caveolin-2 (Cav2)

Recombinant Mouse Caveolin-2 (Cav2)

  • 货号：
    CSB-YP894380MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP894380MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP894380MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP894380MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP894380MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cav2Caveolin-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-162
  • 氨基酸序列
    MGLETEKADV QLFMADDAYS HHSGVDYADP EKYVDSSHDR DPHQLNSHLK LGFEDLIAEP ETTHSFDKVW ICSHALFEIS KYVMYKFLTV FLAIPLAFIA GILFATLSCL HIWILMPFVK TCLMVLPSVQ TIWKSVTDVV IGPLCTSVGR SFSSVSMQLS HD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.
  • 基因功能参考文献：
    1. While structural and functional properties of resistance networks are well maintained in the gluteus muscle of Cav2(-/-) mice, diminished rapid onset vasodilation with greater force production reveals novel physiological roles for Cav2 in skeletal muscle. PMID: 27317631
    2. We concluded that caveolin-2 is most probably involved in regulation of pro-inflammatory responses of BMDMs, triggered via activation of ERK1/2. PMID: 26215374
    3. Cav-2 expressed in tumor microenvironment may potentially become a novel target for cancer therapy PMID: 25269481
    4. In contrast to wild-type-Cav-2, retroviral re-expression of Y19/27F-Cav-2 in Cav-2 knockout endothelial cells did not affect anti-proliferative effect of TGF-beta compared to empty vector. PMID: 22819829
    5. Data show that the balance between caveolin-1 and caveolin-2 is important for iNOS expression and ultimately for sepsis outcome. PMID: 21670588
    6. The negative regulation of transforming growth factor-beta1 signaling and function by caveolin 2 is independent of caveolin 1 expression levels and is not because of changing targeting of caveolin 1 protein to plasma membrane lipid raft/caveolar domains. PMID: 21832243
    7. Data suggest that Cav-2 negatively regulates lung endothelial cell proliferation and cell cycle progression. PMID: 20007452
    8. Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae PMID: 11884617
    9. Splice variant of mouse caveolin-2 mRNA, encoding an isoform lacking the C-terminal domain, localized to the endoplasmic reticulum, while the authentic caveolin-2 was distributed to the Golgi and the plasma membrane along with caveolin-1. PMID: 12054493
    10. Src-induced phosphorylation of caveolin-2 on tyrosine 19. PMID: 12091389
    11. lipid raft-dependent tyrosine phosphorylation of caveolin-2 may be a critical regulator of P. aeruginosa invasion PMID: 15545264
    12. molecular complex most likely to obstruct RACK1 for functional attachment at syndecan-2, as revealed in cells transfected with oncogenic ras PMID: 16997272
    13. skeletal muscle fibers from male Cav-2(-/-) mice show striking abnormalities, such as tubular aggregates, mitochondrial proliferation/aggregation, and increased numbers of M-cadherin-positive satellite cells PMID: 17200204

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.
  • 蛋白家族：
    Caveolin family
  • 数据库链接：

    KEGG: mmu:12390

    STRING: 10090.ENSMUSP00000000058

    UniGene: Mm.396075