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  4. Recombinant Mouse Cell surface glycoprotein CD200 receptor 1 (Cd200r1), partial

Recombinant Mouse Cell surface glycoprotein CD200 receptor 1 (Cd200r1), partial

  • 货号：
    CSB-YP863669MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP863669MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-BP863669MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP863669MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cd200r1; Mox2r; Ox2r; Cell surface glycoprotein CD200 receptor 1; CD200 cell surface glycoprotein receptor; Cell surface glycoprotein OX2 receptor 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli.
  • 基因功能参考文献：
    1. In adoptive therapy of disseminated leukemia, CD200R-CD28-transduced leukemia-specific CD8 T cells eradicated otherwise lethal disease more efficiently than wild-type cells and bypassed the requirement for interleukin-2 administration to sustain in vivo activity. PMID: 29042364
    2. we revealed a critical role for CD200R signaling in limiting the growth and metastasis of CD200(+) tumors. PMID: 27385779
    3. CD200R signaling inhibits pro-angiogenic gene expression by macrophages and suppresses choroidal neovascularization. PMID: 24170042
    4. Data show that neutrophil infiltration of tissues was markedly decreased in CD200 antigen (tg) transgenic animals and increased in CD200 receptor 1 CD200R1(-/-) knockout mice. PMID: 25263452
    5. we show a causal role for the CD200-CD200R inhibitory axis in arteriogenesis in a murine hindlimb ischemia model. PMID: 24897500
    6. CD200-CD200R1 interaction in glial cells is involved in the neuroprotective action of PPAR-gamma agonists. PMID: 24639050
    7. [review] Influenza-infected CD200R1-deficient mice show less bacterial load and exhibit decreased pathogenesis and mortality than wild-type animals following streptococcal pneumonia superinfection. PMID: 24388216
    8. AML1-ETO upregulated CD200R1 in lineage(-) cells, which was characteristic of AML1-ETO-positive leukemia in mice. PMID: 23097187
    9. a role for both graft and host CD200/CD200R expression in increased allograft survival. PMID: 23178470
    10. The main sites of CD200/CD200 receptor (CD200R) interaction in neonates and blood vessels, until adulthood, highlight the possible role of the CD200/CD200R system in microglial development and renewal. PMID: 22323214
    11. CD200R1 does not play an essential role in macrophage homeostasis in the colon. PMID: 22204814
    12. study reports lack of CD200R signaling has a more profound effect on the beneficial but also on the pathological immune responses to viruses in female mice compared to male mice, which can be attributed to the capacity of CD200R to inhibit TLR7 responses PMID: 22615569
    13. It was demonstrated for the first time that the absence of CD200R signaling inhibits outgrowth of an endogenous skin tumor irrespective of CD200 expression by the tumor cells. PMID: 22020332
    14. these results indicate a role of CD200R:CD200 in T cell responses to helminths which has diagnostic and prognostic relevance as a marker of infection for chronic schistosomiasis in mouse and man. PMID: 22496920
    15. Data show thatthat the CD200R1/CD200 pathway is up-regulated in arthritis and plays a significant physiological role in regulating the severity of disease. PMID: 20735439
    16. The CD200 receptor gene family resembles the signal regulatory proteins and killer Ig-related receptors in having receptor family members with potential activatory and inhibitory functions that may play important roles in immune regulation and balance. PMID: 12960329
    17. Murine dendritic cells (DCs) possess a functional CD200R, whose engagement results in the reinforcement or appearance of immunosuppressive properties in these cells. PMID: 15356121
    18. Engagement of CD200R by agonist antibodies or ligand results in a potent inhibition of mast cell degranulation and cytokine secretion responses. PMID: 15661892
    19. Addition to bone-marrow cultures led to generation of dendritic cells that induced a CD4+CD25+) population inhibiting mixed leukocyte culture. PMID: 15880066
    20. results suggest that CD 200:CD 200 R interactions may play a role in regulating both Langerhans cells and dendritic epidermal T cells in cutaneous immune reactions PMID: 16354182
    21. increased endogenous expression of CD200 on osteoblast precursors, or addition of CD200Fc into cultures, led to increased osteoprotogerin PMID: 16530849
    22. CD200:CD200R1 plays an immunoregulatory role in vivo. PMID: 17667818
    23. Interaction between CD200 and its receptor plays a role in modulating microglial activation under conditions of chronic and acute inflammation of the brain. PMID: 17670977
    24. Mice lacking the ligand for CD200R, CD200-/- mice, do not show abnormal composition of the lymphocyte compartment and have normal B cell responses to antigenic challenge. PMID: 17714785
    25. CD200-CD200R axis is therefore a putative regulator of bone mass, via the formation of osteoclasts PMID: 17726108
    26. CD200(-/-) mice exhibit normal myelopoiesis and that development of leukaemia in Dok-1/Dok-2 DKO mice is not caused by a lack of CD200-mediated CD200R signalling. PMID: 17803680
    27. CD200R3 functions as an activating receptor on mast cells and basophils to regulate IgE-independent immune responses in cooperation with an inhibitory receptor CD200R PMID: 17982101
    28. The CD200-CD200R pathway seems of critical relevance for macrophage-mediated damage in autoimmune inflammation of the CNS. PMID: 18164423
    29. LPS-induced changes in CD200-CD200R equilibrium might keep microglia chronically activated. PMID: 19656578

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    CD200R family
  • 组织特异性：
    Expressed in granulocytes, monocytes, most T-cells and a subset of NK, NKT and B-cells (at protein level). Expressed in the spleen, lung, liver, testis, bone marrow, lymph nodes, spinal cord, kidney, uterus and small intestine. Expressed in mast and dendr
  • 数据库链接：

    KEGG: mmu:57781

    STRING: 10090.ENSMUSP00000053822

    UniGene: Mm.416152