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  4. Recombinant Mouse Cellular nucleic acid-binding protein (Cnbp)

Recombinant Mouse Cellular nucleic acid-binding protein (Cnbp)

  • 中文名称：
    Recombinant Mouse Cellular nucleic acid-binding protein(Cnbp),Yeast
  • 货号：
    CSB-YP005637MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Cellular nucleic acid-binding protein(Cnbp),Yeast
  • 货号：
    CSB-EP005637MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Cellular nucleic acid-binding protein(Cnbp),Yeast
  • 货号：
    CSB-EP005637MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Cellular nucleic acid-binding protein(Cnbp),Yeast
  • 货号：
    CSB-BP005637MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Cellular nucleic acid-binding protein(Cnbp),Yeast
  • 货号：
    CSB-MP005637MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cnbp
  • Uniprot No.：
  • 别名：
    Cnbp; Cnbp1; Znf9Cellular nucleic acid-binding protein; CNBP; Zinc finger protein 9
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-178
  • 氨基酸序列
    SSNECFKCG RSGHWARECP TGGGRGRGMR SRGRGGFTSD RGFQFVSSSL PDICYRCGES GHLAKDCDLQ EDEACYNCGR GGHIAKDCKE PKREREQCCY NCGKPGHLAR DCDHADEQKC YSCGEFGHIQ KDCTKVKCYR CGETGHVAIN CSKTSEVNCY RCGESGHLAR ECTIEATA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression. Has a role as transactivator of the Myc promoter. Binds single-stranded RNA in a sequence-specific manner. Binds G-rich elements in target mRNA coding sequences. Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs.
  • 基因功能参考文献：
    1. our study suggests that CNBP could maintain testicular development by inhibiting the Wnt/beta-catenin pathway, particularly by influencing Sertoli cells. PMID: 29743260
    2. A G-rich motif in the lncRNA Braveheart interacts with Cnbp to specify the cardiovascular lineage. PMID: 27618485
    3. data support a role for CNBP as a critical transcription factor and a key regulator of the prolonged expression of sustained cytokine IL-6 during persistent LPS stimulation or Gram-negative bacterial infection PMID: 28168305
    4. CNBP up-regulates tbx2b and smarca5, and down-regulates wnt5b gene expression. PMID: 23667590
    5. expression of APP(Swe) in murine tissue induces a decrease in CNBP expression. PMID: 20621159
    6. CNBP targets Myc in rostral head formation, is essential for forebrain induction and specification. PMID: 12588852

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Endoplasmic reticulum.
  • 数据库链接：

    KEGG: mmu:12785

    STRING: 10090.ENSMUSP00000032138

    UniGene: Mm.290251