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  4. Recombinant Mouse Chloride anion exchanger (Slc26a3), partial

Recombinant Mouse Chloride anion exchanger (Slc26a3), partial

  • 中文名称：
    小鼠Slc26a3重组蛋白
  • 货号：
    CSB-YP894381MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slc26a3重组蛋白
  • 货号：
    CSB-EP894381MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slc26a3重组蛋白
  • 货号：
    CSB-EP894381MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slc26a3重组蛋白
  • 货号：
    CSB-BP894381MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slc26a3重组蛋白
  • 货号：
    CSB-MP894381MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc26a3
  • Uniprot No.：
  • 别名：
    Slc26a3; DraChloride anion exchanger; Down-regulated in adenoma; Protein DRA; Solute carrier family 26 member 3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
  • 基因功能参考文献：
    1. TNFalpha may act reciprocally with DRA, leading to the development of intestinal inflammation. PMID: 29286110
    2. In intestinal cells, TNF activates NF-kappaB, which reduces expression of the Cl(-) / HCO3(-) exchanger SLC26A3, via direct binding to the promoter region. PMID: 28823863
    3. This study showed that transepithelial sulfate fluxes across the mouse distal ileum demonstrating that DRA (and to a lesser extent, PAT1) secretes sulfate with significant implications for intestinal sulfate absorption and overall homeostasis. PMID: 28526688
    4. expressed in ameloblasts but not alone critical for formation of dental enamel PMID: 26394631
    5. DRA surface expression was reduced partly via an increase in DRA endocytosis and a decrease in exocytosis PMID: 26447204
    6. Both PAT-1 and DRA significantly contribute to intestinal fluid absorption and enterocyte acid/base balance but are activated by different ion gradients. PMID: 24233434
    7. Data demonstrate an upregulation of SLC26A3 via activation of the ERK1/2 pathway that may underlie potential antidiarrheal effects of Bifidobacterium sp. PMID: 25143346
    8. Data indicate that solute carrier family 26, member 3 protein (Slc26a3) is expressed in male reproductive tract, and its expression pattern is related to the function. PMID: 25297603
    9. Deletion of DRA results in severely reduced colonic HCO3 (-) secretory rate, a loss of colonic fluid absorption, a lack of a firmly adherent mucus layer and a severely reduced colonic mucosal resistance to dextran sodium sulphate damage. PMID: 24373192
    10. Efficacy of lactobacillus acidophilus or its secreted soluble factors in alleviating inflammation and inflammation-associated dysregulation of DRA activity could justify their therapeutic potential in inflammatory diarrheal diseases. PMID: 25059823
    11. DRA mediates a predominance of the apical uptake of oxalate and Cl(-) absorbed in the small and large intestine of mice under short-circuit conditions. PMID: 23886857
    12. Endogenous and recombinant human/mouse Slc26a3 do not exhibit electrogenic 2Cl-/1HCO- exchange. Acute induction of Slc26a3 Cl-/HCO3- exchange is associated with secondary membrane potential changes representing homeostatic responses. PMID: 21068358
    13. demonstrate that the double-mutant mice present with a defect in intestinal water absorption and that Hnf1alpha and beta directly control the expression of Slc26a3. PMID: 20388655
    14. Increase in DRA promoter activity and expression may contribute to the upregulation of intestinal electrolyte absorption and might underlie the potential antidiarrheal effects of Lactobacillus acidophilus. PMID: 20044511
    15. In Slc26a6-knockout mice, a robust Slc26a3 compensatory upregulation can replace the function of Slc26a6 in pancreatic ducts. PMID: 16901991
    16. slc26a3 is the major apical chloride/base exchanger and is essential for the absorption of chloride in the colon. In addition, slc26a3 regulates colonic crypt proliferation. PMID: 17001077
    17. Dra activity contributes most basal HCO(3)(-) secretion and approximately 50% of cAMP-stimulated HCO(3)(-) secretion in duodenum PMID: 19121635

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  • 亚细胞定位：
    Apical cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail.
  • 蛋白家族：
    SLC26A/SulP transporter (TC 2.A.53) family
  • 组织特异性：
    Expressed in spermatogenic cells.
  • 数据库链接：

    KEGG: mmu:13487

    STRING: 10090.ENSMUSP00000001254

    UniGene: Mm.490454