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  4. Recombinant Mouse Choline/ethanolamine kinase (Chkb)

Recombinant Mouse Choline/ethanolamine kinase (Chkb)

  • 中文名称：
    Recombinant Mouse Choline/ethanolamine kinase(Chkb),Yeast
  • 货号：
    CSB-YP005354MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Choline/ethanolamine kinase(Chkb),Yeast
  • 货号：
    CSB-EP005354MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Choline/ethanolamine kinase(Chkb),Yeast
  • 货号：
    CSB-EP005354MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Choline/ethanolamine kinase(Chkb),Yeast
  • 货号：
    CSB-BP005354MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Choline/ethanolamine kinase(Chkb),Yeast
  • 货号：
    CSB-MP005354MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Chkb
  • Uniprot No.：
  • 别名：
    Chkb; Chetk; ChklCholine/ethanolamine kinase; Choline kinase beta; CK; CKB; EC 2.7.1.32; Ethanolamine kinase; EK; EC 2.7.1.82; choline/ethanolamine kinase beta; CKEKB
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-394
  • 氨基酸序列
    AADGTGVVG GGAVGGGLPK DGLQDAKCPE PIPNRRRASS LSRDAQRRAY QWCREYLGGA WRRARPEELS VCPVSGGLSN LLFRCSLPNH VPSVGGEPRE VLLRLYGAIL QGVDSLVLES VMFAILAERS LGPQLYGVFP EGRLEQYLPS RPLKTQELRD PVLSGAIATR MARFHGMEMP FTKEPRWLFG TMERYLKQIQ DLPSTSLPQM NLVEMYSLKD EMNSLRKLLD DTPSPVVFCH NDIQEGNILL LSEPDSDDNL MLVDFEYSSY NYRGFDIGNH FCEWVYDYTY EEWPFYKARP TDYPTREQQL HFIRHYLAEV QKGEILSEEE QKKREEELLL EISRYSLASH FFWGLWSTLQ ASMSTIEFGY LEYAQSRFQF YFQQKGQLTS SPSS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Has a key role in phospholipid metabolism, and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesis.
  • 基因功能参考文献：
    1. CHKB is a new modulator of bone homeostasis PMID: 25451916
    2. Our data indicate that choline kinase beta plays an important role in endochondral bone formation by modulating growth plate physiology. PMID: 24637075
    3. Loss of choline kinase beta in skeletal muscle causes mitochondrial dysfunction and increased mitophagy. PMID: 21750112
    4. Experimental evidence for the presence of heteromeric ChoK/EtnK in any source. The activity of ChoK/EtnK in the cell is controlled not only by the level of each isoform but also by their combination to form the active oligomer complex. PMID: 11964179
    5. choline kinase beta is the first enzyme in phosphatidylcholine biosynthesis and has a role in rostrocaudal muscular dystrophy PMID: 16371353
    6. Mutation of the corresponding D276 of CK-beta to A276 did not show any effect on either its homo- or hetero-dimerization but it caused a strong inhibition of CK activity in either case. PMID: 16490392
    7. The hindlimb muscular dystrophy in Chkb -/- mice is due to attenuated phosphatidylcholine biosynthesis and enhanced catabolism of phosphatidylcholine. PMID: 19236939

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  • 相关疾病：
    Defects in Chkb are a cause of rostrocaudal muscular dystrophy (rmd). The disease is characterized by rapidly progressive muscular dystrophy and neonatal forelimb bone deformity. The dystrophy is only evident in skeletal muscle tissues in an unusual rostral-to-caudal gradient.
  • 蛋白家族：
    Choline/ethanolamine kinase family
  • 组织特异性：
    Expressed ubiquitously with the highest level in testis.
  • 数据库链接：

    KEGG: mmu:12651

    STRING: 10090.ENSMUSP00000023289

    UniGene: Mm.485045