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  4. Recombinant Mouse Chromobox protein homolog 8 (Cbx8)

Recombinant Mouse Chromobox protein homolog 8 (Cbx8)

  • 中文名称：
    Recombinant Mouse Chromobox protein homolog 8(Cbx8),Yeast
  • 货号：
    CSB-YP889560MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Chromobox protein homolog 8(Cbx8),Yeast
  • 货号：
    CSB-EP889560MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Chromobox protein homolog 8(Cbx8),Yeast
  • 货号：
    CSB-EP889560MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Chromobox protein homolog 8(Cbx8),Yeast
  • 货号：
    CSB-BP889560MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Chromobox protein homolog 8(Cbx8),Yeast
  • 货号：
    CSB-MP889560MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cbx8
  • Uniprot No.：
  • 别名：
    Cbx8; Pc3; Chromobox protein homolog 8; Polycomb 3 homolog; Pc3; mPc3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-362
  • 氨基酸序列
    MELSAVGERV FAAEALLKRR IRKGRMEYLV KWKGWSQKYS TWEPEENILD ARLLAAFEER EREMELYGPK KRGPKPKTFL LKAQAKAKAK TYEFRSDSTR GIRIPYPGRS PQDLASTSRA REGLRNTGLP PPGSSTSTCR ADPPRDRDRE RDRGTSRVDD KPSSPGDSSK KRGPKPRKEP LDPSQRPLGE PSAGLGEYLK GRKLDETSSG TGKFPAGHSV IQLARRQDSD LVQYGVTSPS SAEASSKLAV DTFPARVIKH RAAFLEAKGQ GALDPGGARV RHSSGTPASV GSLYRDMGAQ GGRPSLIARI PVARILGDPE EESWSPSLTN LEKVVVTDVT SNFLTVTIKE SNTDQGFFKE KR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
  • 基因功能参考文献：
    1. Cbx8 associates with non-PRC1 complexes containing the H3K4 methyltransferase complex component WDR5, which together regulate Notch gene expression. PMID: 27346354
    2. CBX8 plates roles in epigenetic regulation in DNA damage response. PMID: 27555324
    3. Cbx8 is upregulated and recruited to activated genes during embryonic stem cell differentiation. PMID: 25500566
    4. CBX8 plays an essential role in MLL-AF9 transcriptional regulation and leukemogenesis. PMID: 22094252
    5. Pcl2-PRC2 facilitates both PRC2 recruitment to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. PMID: 21367819
    6. Huntingtin is a novel stimulator of polycomb repressive complex 2. PMID: 19933700

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  • 亚细胞定位：
    Nucleus. Chromosome.
  • 数据库链接：

    KEGG: mmu:30951

    STRING: 10090.ENSMUSP00000026663

    UniGene: Mm.99953