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  4. Recombinant Mouse Complement component receptor 1-like protein (Cr1l), partial

Recombinant Mouse Complement component receptor 1-like protein (Cr1l), partial

  • 中文名称：
    Recombinant Mouse Complement component receptor 1-like protein(Cr1l),partial,Yeast
  • 货号：
    CSB-YP717575MO1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Complement component receptor 1-like protein(Cr1l),partial,Yeast
  • 货号：
    CSB-EP717575MO1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Complement component receptor 1-like protein(Cr1l),partial,Yeast
  • 货号：
    CSB-BP717575MO1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Complement component receptor 1-like protein(Cr1l),partial,Yeast
  • 货号：
    CSB-MP717575MO1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cr1l
  • Uniprot No.：
  • 别名：
    Cr1l; Crry; CryComplement component receptor 1-like protein; Complement regulatory protein Crry; Protein p65
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion.
  • 基因功能参考文献：
    1. CRRY role in the retinal epithelium and photoreceptor degeneration PMID: 28348233
    2. this study has provided direct evidence for a role of Crry in controlling spontaneous alternative pathway complement activation on renal tubular epithelial cells. PMID: 24850152
    3. Crry costimulation enhanced the in vitro expansion of natural Treg cells while maintaining their phenotypic and suppressive properties. Crry-expanded Treg cells decreasing antigen-dependent secretion of cytokines. PMID: 21380996
    4. Stmn2 and the chromosome 14 Rarb region, but not Cr1 or Clu or Picalm, have roles in prion disease. PMID: 21151910
    5. Crry is clearly present in the placentas from spontaneous abortions in mice. PMID: 20484840
    6. Crry is the only membrane-bound complement regulator expressed on the basolateral surface of murine renal tubular epithelial cells under in vitro culture conditions. PMID: 20675597
    7. Data show that a single-nucleotide polymorphism in the first short consensus repeat of Sle1c Crry introduced a novel N-linked glycosylation site likely responsible for structural alteration. PMID: 20660348
    8. mesangial cell Crry limits complement activation and subsequent neutrophil recruitment in the setting of local immune complex deposition. PMID: 19740350
    9. Long-term complement blockade with Crry, a C3 convertase inhibitor overexpressed in a transgenic mouse line, reduces renal disease and improves survival in lupus-prone MRL/lpr mice. PMID: 11907125
    10. the role of crry in regulating complement regulation PMID: 11915940
    11. Crry is indispensable for erythrocyte protection from spontaneous complement attack PMID: 11986227
    12. Crry plays a more dominant role than DAF in regulating the alternative pathway of complement C3 activation, whereas DAF and Crry are equally effective in preventing antibody-induced runaway complement activation. PMID: 12393518
    13. X-ray and neutron scattering was performed on recombinant rat Crry containing the first five SCR domains (rCrry) and mouse Crry with five SCR domains conjugated to the Fc fragment of mouse IgG1 (mCrry-Ig) PMID: 12767833
    14. Mice transgenic for murine complement inhibitor Crry are largely protected from developing collagen-induced arthritis. PMID: 12902517
    15. Data demonstrate that transgenic mice with astrocyte-targeted expression of the soluble complement inhibitor sCrry have a significantly reduced neurologic impairment and improved blood-brain barrier function after closed head injury. PMID: 12973023
    16. The dual function of Crry as a complement regulatory protein and as a T cell costimulator illustrates the importance of complement regulatory proteins as links between innate and adaptive immunity. PMID: 16301324
    17. Results suggest that altered expression of Crry within the tubular epithelium appears to be a critical factor permitting activation of the alternative pathway of complement after ischemia/reperfusion. PMID: 16444293
    18. both a high level expression and a more potent anti-alternative pathway complement activity of Crry contributed to its indispensable role on murine erythrocytes PMID: 17015743
    19. Our data suggest complement provides some protection of mature oligodendrocytes during cuprizone treatment but may be critical for subsequent remyelination events. PMID: 17674370
    20. DAF and Crry double deficiency led to rapid clearance of platelets from circulation in a complement- and macrophage-dependent manner; redundant role of DAF and Crry in platelet survival PMID: 18524992
    21. Membrane complement regulator Crry helps to maintain homeostasis of the complement alternative pathway (AP) and demonstrates that Crry-deficient mice can be rescued on a partial as well as on a complete factor B- or C3-deficient maternal background. PMID: 18684964
    22. Pak1 is an essential molecular target for modulating acute mast cell responses that contribute to allergic diseases. PMID: 19124833
    23. Crry is essential for mature T-cell survival in the periphery but not for lymphogenesis in the thymus. PMID: 19136662
    24. Crry and CD59 are critical in protecting Treg cells from complement mediated injuries. PMID: 19281793

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Receptors of complement activation (RCA) family
  • 组织特异性：
    Ubiquitously expressed (at protein level).
  • 数据库链接：

    KEGG: mmu:12946

    UniGene: Mm.301652