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  4. Recombinant Mouse Copper chaperone for superoxide dismutase (Ccs)

Recombinant Mouse Copper chaperone for superoxide dismutase (Ccs)

  • 货号：
    CSB-YP004854MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP004854MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP004854MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP004854MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP004854MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ccs
  • Uniprot No.：
  • 别名：
    Ccs; Ccsd; Copper chaperone for superoxide dismutase; Superoxide dismutase copper chaperone
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-274
  • 氨基酸序列
    MASKSGDGGT VCALEFAVQM SCQSCVDAVH KTLKGVAGVQ NVDVQLENQM VLVQTTLPSQ EVQALLESTG RQAVLKGMGS SQLQNLGAAV AILEGCGSIQ GVVRFLQLSS ELCLIEGTID GLEPGLHGLH VHQYGDLTRD CNSCGDHFNP DGASHGGPQD TDRHRGDLGN VRAEAGGRAT FRIEDKQLKV WDVIGRSLVI DEGEDDLGRG GHPLSKITGN SGKRLACGII ARSAGLFQNP KQICSCDGLT IWEERGRPIA GQGRKDSAQP PAHL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Delivers copper to copper zinc superoxide dismutase (SOD1).
  • 基因功能参考文献：
    1. results suggest that a SOD1 supplement to healthy mice may not be necessary to modulate cell proliferation and neuroblast differentiation in the dentate gyrus PMID: 21927927
    2. Small interfering RNA (siRNA) targeting CCS was introduced into metallothionein-knockout mouse fibroblasts (MT-KO cells) and their wild type cells (MT-WT cells) to reveal the interactive role of CCS with other Cu-regulating proteins. PMID: 21409224
    3. CCS is necessary for the efficient incorporation of copper into SOD1 in motor neurons, but it does not modify the onset and progression of motor neuron disease in SOD1-mutant mice. PMID: 11889469
    4. CCS-independent activation of mammalian SOD1 involves glutathione PMID: 15069187
    5. Associated with copper deficiency were higher levels of Ccs in erythrocytes. PMID: 15337829
    6. A mechanism determining the abundance of CCS that is competitive with the process of copper delivery to SOD1 is described, revealing a unique post-translational component of intracellular copper homeostasis. PMID: 16531609
    7. These results establish that CCS/G93A SOD1 mice manifest an isolated complex IV deficiency which may underlie a substantial part of mutant SOD1-induced mitochondrial cytopathy. PMID: 18334481
    8. Study finds that as expected, CCS over-expression promotes oxidation of a wild-type SOD1 disulfide; however, in the diseased G93A/CCS mouse, there was no increased oxidation of the mutant SOD1 disulfide. PMID: 18337307
    9. effects of copper chaperone for SOD1 on mitochondrial dysfunction are SOD1 mutation dependent and correlate with SOD1 redox susceptibility PMID: 19320055

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Cu-Zn superoxide dismutase family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    KEGG: mmu:12460

    STRING: 10090.ENSMUSP00000035486

    UniGene: Mm.434411