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Recombinant Mouse Cortistatin (Cort)

  • 中文名称：
    Recombinant Mouse Cortistatin(Cort),Yeast
  • 货号：
    CSB-YP005821MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Cortistatin(Cort),Yeast
  • 货号：
    CSB-EP005821MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Cortistatin(Cort),Yeast
  • 货号：
    CSB-EP005821MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Cortistatin(Cort),Yeast
  • 货号：
    CSB-BP005821MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Cortistatin(Cort),Yeast
  • 货号：
    CSB-MP005821MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cort
  • Uniprot No.：
  • 别名：
    CortCortistatin [Cleaved into: Cortistatin-14]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    96-109
  • 氨基酸序列
    PCKNF FWKTFSSCK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice. PMID: 27901064
    2. Endogenous SST and CORT distinctly impact on DMBA-induced mammary gland tumorigenesis , in a manner that is strongly dependent on the metabolic/endocrine milieu (lean vs. obese status). PMID: 26956474
    3. This study demonistrated that Cortistatin attenuates inflammatory pain via spinal and peripheral actions. PMID: 24333694
    4. endogenous CORT is essential for the obesity-induced changes in insulin expression/secretion observed in mice PMID: 23469081
    5. Cortistatin emerges as a natural endogenous regulator of smooth muscle cells under pathological conditions and an attractive candidate for the pharmacological management of vascular diseases that course with neointimal lesion formation. PMID: 23595952
    6. the role of endogenous CST is different from SST; CST exerted an unexpected stimulatory role on prolactin secretion PMID: 21971153
    7. Cortistatin mRNA concentration in the hippocampus and dentate gyrus is significantly increased in aged non-transgenic (Tg) mice compared with young non-Tg mice. PMID: 15364032

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Somatostatin family
  • 组织特异性：
    Expressed in a subset of GABAergic cells in the cortex and hippocampus.
  • 数据库链接：

    KEGG: mmu:12854

    STRING: 10090.ENSMUSP00000030815

    UniGene: Mm.6204