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  4. Recombinant Mouse Cyclic AMP-dependent transcription factor ATF-1 (Atf1)

Recombinant Mouse Cyclic AMP-dependent transcription factor ATF-1 (Atf1)

  • 货号：
    CSB-YP002269MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP002269MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP002269MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP002269MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP002269MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Atf1
  • Uniprot No.：
  • 别名：
    Atf1Cyclic AMP-dependent transcription factor ATF-1; cAMP-dependent transcription factor ATF-1; Activating transcription factor 1; TCR-ATF1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-269
  • 氨基酸序列
    MEDSHKSNTT ETASQPGSTV AGPHVSQIVH QVSSLSESEE SQDSSDSIGS SQKAHGILAR RPSYRKILKD LSSEDTRGRK GEGENPSISA ITSMSVPAPI YQTSSGQYIA IAPNGALQLA SPSTDGVQAL QTLTMTNSSS TQQGTILQYA QTSDGQQILV PSNQVVVQTA SGDMQTYQIR TTPSATSLPQ TVVMTSPVTL ASQTTKTDDP QLRREIRLMK NREAARECRR KKKEYVKCLE NRVAVLENQN KTLIEELKTL KDLYSHKSV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
  • 基因功能参考文献：
    1. the HSF1 complex, including BRG1 and lysine acetyltransferases p300 and CREB-binding protein (CBP), is formed in a manner dependent on the phosphorylation of ATF1 PMID: 25312646
    2. conclude that HO-1 regulates DC maturation and function by modulating the p38 MAPK-CREB/ATF1 signaling axis PMID: 24719331
    3. Dehydroepiandrosterone sulfate (DHEAS)-induced signaling is mediated through interaction with a membrane-bound G-protein-coupled receptor, since silencing of Gnalpha11 leads to the abolition of the DHEAS-induced stimulation of Erk1/2, ATF-1, and CREB. PMID: 23988737
    4. indicate that dysregulation of p38 MAPK-CREB/ATF1 signaling axis underlies the altered function and phenotype in Nrf2-deficient DCs PMID: 23775080
    5. Forced expression of EWS/ATF1 resulted in the development of EWS/ATF1-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1-driven transformation. PMID: 23281395
    6. miR-34c functions, at least partially, by targeting the ATF1 gene in germ cell apoptosis, providing a novel mechanism with involvement of miRNA in the regulation of germ cell apoptosis. PMID: 22479460
    7. ATF1 is a novel substrate of RSK2 and that RSK2-ATF1 signaling plays an important role in EGF-induced neoplastic cell transformation. PMID: 21098035
    8. study demonstrates a role for trophic signaling and constitutive activation of activating transcription factor 1(Atf1) and cAMP response element-binding protein (CREB) at the time of zygotic genome activation PMID: 19776387
    9. MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. PMID: 11909979
    10. role in hippocampus-dependent learning PMID: 11988175
    11. phosphorylation by the ERK MAPK pathway is required for epidermal growth factor-induced c-jun expression PMID: 12414794
    12. ATF1 plays a central role in adipogenesis because expression of individual master adipogenic regulators is unable to compensate for its loss. Depletion of ATF1 blocks adipogenesis in vitro and in vivo. PMID: 17071615
    13. Leptin signaling in a clonal population of mouse neurotensin (NT)-expressing hypothalamic neurons, N-39, is reported. PMID: 17077290
    14. PIAS3 is a new regulator of ATF1 that regulates the ARE-mediated transcription of the ferritin H gene PMID: 17565989
    15. ATF-1, via p38 MAP kinase activation, functions as a novel regulatory pathway driving UCP3 expression PMID: 18579531

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family, ATF subfamily
  • 数据库链接：

    KEGG: mmu:11908

    STRING: 10090.ENSMUSP00000023769

    UniGene: Mm.676