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Recombinant Mouse Cyclin-D1-binding protein 1 (Ccndbp1)

  • 中文名称：
    Recombinant Mouse Cyclin-D1-binding protein 1(Ccndbp1),Yeast
  • 货号：
    CSB-YP659703MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Cyclin-D1-binding protein 1(Ccndbp1),Yeast
  • 货号：
    CSB-EP659703MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Cyclin-D1-binding protein 1(Ccndbp1),Yeast
  • 货号：
    CSB-EP659703MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Cyclin-D1-binding protein 1(Ccndbp1),Yeast
  • 货号：
    CSB-BP659703MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Cyclin-D1-binding protein 1(Ccndbp1),Yeast
  • 货号：
    CSB-MP659703MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ccndbp1
  • Uniprot No.：
  • 别名：
    Ccndbp1; Dip1; Gcip; Maid; Cyclin-D1-binding protein 1; Grap2 and cyclin-D-interacting protein; Maternal Id-like protein; Stage specific embryonic cDNA-8 protein; SSEC-8
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-356
  • 氨基酸序列
    ASSTAAVPF LAPPLEQLRH LAEELRSLLP RVRVGEAQET AEEFNREMFW RRLNEAAVKV NGEATVLTTH FSKLPWPSPQ ETQRICEQVR IAIEEIIIVY YSLPKDQGIT LRKLVRNAAL DIVDGMAQLL EVLLTAPSQS TENGDLISCN SVSVACQQVP EIPKDNKAAA LLMLTKSVDF VKDAHEEMEQ AVEECDPYSG LLNDSEDNSD SHSDEDGVLG LPSNRDSYWS EEDQELIIPC LALVRASRAS LKKIRILVAE NGKKDEVAQL DDIVDISDEI SPSVDDLVLS IYPPVCHLTV RISSAKLVSV LIKALEITKA SHVSPHPGDS WIPLLINAVD HCMNRIKALT QRAAEL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription. May be required for hepatocyte proliferation.
  • 基因功能参考文献：
    1. Ccndbp1 is a positive modulator of skeletal myogenic differentiation in vivo and in vitro. PMID: 27235421
    2. Data suggest Maid/Ccndbp1 inhibits cell migration induced by TGFB1 (transforming growth factor-beta1) but not by BMP4 (bone morphogenetic protein-4); Maid does not alter cell proliferation, epithelial-mesenchymal transition, or TGFB3-induced apoptosis. PMID: 26002959
    3. These results indicate that Maid is involved in G1/S-phase progression of hepatocytes, which in older animals is associated with the development of liver tumors. PMID: 17256742
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CCNDBP1 family
  • 组织特异性：
    Expressed at high levels in brain, intestine, muscle and ovary and at lower levels in heart, kidney, liver, lung, spleen and testis.
  • 数据库链接：

    KEGG: mmu:17151

    STRING: 10090.ENSMUSP00000062496

    UniGene: Mm.7838