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  4. Recombinant Mouse Cyclin-dependent kinase 4 inhibitor B (Cdkn2b)

Recombinant Mouse Cyclin-dependent kinase 4 inhibitor B (Cdkn2b)

  • 货号：
    CSB-YP005092MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP005092MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP005092MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP005092MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP005092MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cdkn2bCyclin-dependent kinase 4 inhibitor B; p14-INK4b; p15-INK4b
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-130
  • 氨基酸序列
    MLGGSSDAGL ATAAARGQVE TVRQLLEAGA DPNALNRFGR RPIQVMMMGS AQVAELLLLH GAEPNCADPA TLTRPVHDAA REGFLDTLVV LHRAGARLDV CDAWGRLPVD LAEEQGHRDI ARYLHAATGD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
  • 基因功能参考文献：
    1. miR-541 contributes to microcystin-LR-induced testicular toxicity by regulating the expression of p15 and promoting apoptosis. PMID: 27608041
    2. Loss of CDKN2B may not only promote cardiovascular disease through the development of atherosclerosis but may also impair TGFbeta signaling and hypoxic neovessel maturation. PMID: 26596284
    3. Radiation-induced double strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate high-grade gliomas that are commonly driven by Met amplification and activation. PMID: 24632607
    4. Data indicate that loss of cyclin-dependent kinase inhibitor p15 (p15Ink4b) collaborates with oncogene fusion protein Nup98-HoxD13 transgene in the development of predominantly myeloid neoplasms. PMID: 24449168
    5. Loss of CDKN2B promotes atherosclerosis by increasing the size and complexity of the lipid-laden necrotic core through impaired efferocytosis. PMID: 24531546
    6. Reduced CDKN2B expression and increased p53-dependent smooth muscle cell apoptosis may be one mechanism underlying the 9p21.3 association with aneurysmal disease. PMID: 23162013
    7. mRNA expression of p15 gene in mouse bone marrow cells decreases after exposure to 1,4-benzoquinone, but the CpG islands methylation status in promoter is not affected. PMID: 21619792
    8. p15Ink4b is an important modulator of cDC development and has a novel function for this tumor suppressor in the regulation of adaptive immune responses. PMID: 22461492
    9. findings indicate that in lymphoid tissue the inactivation of both p15 alleles is unlikely to be the first event in tumor development PMID: 22227036
    10. new animal model demonstrates experimentally that p15Ink4b is a tumor suppressor for myeloid leukemia, and its loss may play an active role in the establishment of preleukemic conditions PMID: 20457873
    11. is not consistently inactivated in murine myeloid cells transformed in vivo by deregulated c-Myc PMID: 12642863
    12. Ink4b is hypermethylated in murine myeloid leukemia PMID: 14681685
    13. review experiments and present examples of new models of myeloid leukemia where retroviruses have collaborated with a transgene [Cbfbeta-MYH111 from Inv(16)] and with loss of a tumor suppressor (Ink4b) mice to induce leukemia. PMID: 14757439
    14. regulation of the Ink4b promoter is apparently myeloid specific because both ICSBP and PU.1 are myeloid commitment factors. PMID: 14976051
    15. results strongly suggest that p15(Ink4b) loss must be accompanied by additional oncogenic changes for RUNX1-ETO-associated acute myeloid leukemia to develop PMID: 18037485
    16. Expression of exogenous p15AS in mouse embryonic stem cells caused p15 silencing and increased growth, through heterochromatin formation, as well as DNA methylation after differentiation of the embryonic stem cells PMID: 18185590
    17. Results indicate that Jhdm1b is an H3K36 demethylase that regulates cell proliferation and senescence through p15(Ink4b). PMID: 18836456

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  • 蛋白家族：
    CDKN2 cyclin-dependent kinase inhibitor family
  • 组织特异性：
    Expressed ubiquitously.
  • 数据库链接：

    KEGG: mmu:12579

    STRING: 10090.ENSMUSP00000095595

    UniGene: Mm.423094