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  4. Recombinant Mouse Cytokine-dependent hematopoietic cell linker (Clnk)

Recombinant Mouse Cytokine-dependent hematopoietic cell linker (Clnk)

  • 货号：
    CSB-YP005571MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP005571MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP005571MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP005571MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP005571MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Clnk
  • Uniprot No.：
  • 别名：
    Clnk; MistCytokine-dependent hematopoietic cell linker; Mast cell immunoreceptor signal transducer
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-435
  • 氨基酸序列
    MTSQGNKRTT KEGFGDLRFQ NVSLLKNRSW PSLSSAKGRC RAVLEPLPDH RRNLAGVPGG EKCNSNNDYE DPEFQLLKAW PSMKILPARP IQESEYADTR YFQDTMEAPL LLPPKASVST ERQTRDVRMT HLEEVDKPTF KDVRSQRFKG FKYTKINKTP LPPPRPAITL PKKYQPLPPA PPEESSAYFA PKPTFPEVQR GPRQRSAKDF SRVLGAEEES HHQTKPESSC PSSNQNTQKS PPAIASSSYM PGKHSIQARD HTGSMQHCPA QRCQAAASHS PRMLPYENTN SEKPDPTKPD EKDVWQNEWY IGEYSRQAVE DVLMKENKDG TFLVRDCSTK SKAEPYVLVV FYGNKVYNVK IRFLESNQQF ALGTGLRGNE MFDSVEDIIE HYTYFPILLI DGKDKAARRK QCYLTQPLPL ARLLLTQYSS QALHE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    An adapter protein which plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Together with FGR, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production. Acts as a positive regulator of both T-cell receptor and natural killer T (NKT) cell receptor signaling in CD4-positive NKT cells. Together with MAP4K1, it enhances CD3-triggered activation of T-cells and subsequent IL2 production. May be involved in tumor necrosis factor induced cell death by promoting reactive oxidative species generation, and MLKL oligomerization, ultimately leading to necrosis. Involved in phosphorylation of LAT. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.
  • 基因功能参考文献：
    1. Clnk is dispensable for normal differentiation and function of T cells, mast cells, and NK cells. Hence, unlike its relatives, Clnk is not essential for normal immune functions PMID: 15199160
    2. STAT5 is involved in cytokine-mediated up-regulation of MIST gene expression, in collaboration with other lineage-specific transcription factors that promote basal MIST expression in mast cells. PMID: 15358227
    3. interaction of MIST with Fgr, mediated by the C-terminal proline-rich region of MIST and the SH3 domain of Fgr, was required for the suppression of NK-cell receptor-induced IFN-gamma production PMID: 16439675
  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Expressed in T-cells, mast cells, natural killer and natural killer T cells (at protein level). Expressed in cytokine-stimulated hemopoietic cells.
  • 数据库链接：

    KEGG: mmu:27278

    STRING: 10090.ENSMUSP00000128473

    UniGene: Mm.440845