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  4. Recombinant Mouse D-glucuronyl C5-epimerase (Glce), partial

Recombinant Mouse D-glucuronyl C5-epimerase (Glce), partial

  • 中文名称：
    小鼠Glce重组蛋白
  • 货号：
    CSB-YP875333MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Glce重组蛋白
  • 货号：
    CSB-EP875333MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Glce重组蛋白
  • 货号：
    CSB-EP875333MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Glce重组蛋白
  • 货号：
    CSB-BP875333MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Glce重组蛋白
  • 货号：
    CSB-MP875333MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Glce
  • Uniprot No.：
  • 别名：
    Glce; D-glucuronyl C5-epimerase; EC 5.1.3.17; Heparan sulfate C5-epimerase; Hsepi; Heparin sulfate C5-epimerase; Heparin/heparan sulfate:glucuronic acid C5-epimerase; Heparosan-N-sulfate-glucuronate 5-epimerase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins.
  • 基因功能参考文献：
    1. Results found that loss of Glce leads to a delayed onset of hypertrophic differentiation combined with an expanded region of proliferating chondrocytes indicating increased Ihh signaling. PMID: 26116392
    2. analysis of the activity of heparan sulfate C5-epimerase and its mutants by using engineered 2-O-sulfotransferase PMID: 20118238
    3. modification of heparan sulfate by glucuronyl C5-epimerase is required for controlling the activity of molecules that are instructive for early lymphoid tissue morphogenesis PMID: 20208005
    4. NDST-1 and C5-epimerase have roles in heparan sulfate structure alterations in mouse tissue PMID: 15292174
  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    D-glucuronyl C5-epimerase family
  • 组织特异性：
    Widely expressed with highest levels in lung and lowest levels in spleen.
  • 数据库链接：

    KEGG: mmu:93683

    STRING: 10090.ENSMUSP00000034785

    UniGene: Mm.24411