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  4. Recombinant Mouse Dapper homolog 2 (Dact2)

Recombinant Mouse Dapper homolog 2 (Dact2)

  • 货号：
    CSB-YP752630MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP752630MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP752630MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP752630MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP752630MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dact2
  • Uniprot No.：
  • 别名：
    Dact2; Dpr2; Frd2; Dapper homolog 2; mDpr2; Dapper antagonist of catenin 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-757
  • 氨基酸序列
    MWAPSGQGPA GWDRRRVGAR LRAALAGLQE LQGLRATQQA RVRGALGLHP APGPRGQELR LEAALTALRE QLSRLRRQDA GLKTHLDQLD QQISELQLDV SRSSCEALDS DSRPSSGFYE LSDAGSCSLS TSCASVCSDR LSPSLGSWLP VFQPSKSRSG IGDWRPRSAD ETTVPAWSPQ LTEDSRLLHG AEGTGRLTGM FRPRPVSTGD LERVLPADVG LQRAGTDAAH LLGQGIEIPA HALDPTYQRD LVARGGQEVY PYPSPLHAVA LQSPLFALPK EAPCFDICSP PQEPPLVPVD ENRTQPEPIR ELGSAEAYIH RLLHLRGQEL PLRDVGQEQG GDTAAFPPKP CGQRSESTCQ LEKQACGADR GGLKLGRGAA KDSLKQHGPV SLVGAEPLSS PLKEETIPWN PCVHGDNTVG SSPCSQAQQP LNDCGQGPVL SPSRVLGTES PPLAPEPFAY TSCTTGETSP VKLRMGFSQN KAVKVRRRVS EKVPRLGKQL PPQPERQRVT ERDPSRPHQG GLSRRPTLAR EPPGRSCSES TLYPVPFLVP VVVAQRESYP TSPQAFFPME AALLSSAARR KQRRWQSTME ISAKAGSVSQ PGPSMGLPRS PAKRGSGPRA QSRPTLARQD ACARCESDPS EHSADCTSLY HSTIAETSED EEASDHTANR FGDESSSNDS EGCFRGSRRR LAIGSAEAGQ GGWAWPRVPP QQPSRAPGNT RPPLPPVPKL CRIKASKALK KKIRRFQPAA LKVMTMV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling.
  • 基因功能参考文献：
    1. we have identified a novel role for Dact2 as an inhibitor of the canonical Wnt pathway in embryonic tooth development through its regulation of cell proliferation and differentiation. PMID: 23349981
    2. conserved role for Dact2 protein in kinase-regulated biochemistry involving Vangl and Dvl. PMID: 21718540
    3. Dact2 plays a role in regulating morphogenesis by renal collecting duct cells, probably by protecting cells from overly strong TGF-beta pathway activation. PMID: 20685821
    4. Dact2 may play important signal-modulating roles in the adjacent epithelial cells including the enamel knot signaling centers and pre-ameloblasts. PMID: 20170752
    5. Dact2 expression is most prominent during organogenesis of the thymus, kidneys, and salivary glands, with much lower levels in the somites and in the developing CNS. PMID: 16881060
    6. Dpr2 plays an inhibitory role in the re-epithelialization of adult skin wounds by attenuating TGFbeta signaling. PMID: 18716284

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  • 蛋白家族：
    Dapper family
  • 组织特异性：
    Expressed in kidney (inner medullary collecting duct). Expressed in epidermal keratinocytes and hair follicles.
  • 数据库链接：

    KEGG: mmu:240025

    STRING: 10090.ENSMUSP00000051638

    UniGene: Mm.79993