Recombinant Mouse Death domain-associated protein 6 (Daxx)
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货号:CSB-YP006507MO
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规格:
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来源:Yeast
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其他:
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货号:CSB-EP006507MO
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规格:
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来源:E.coli
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其他:
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货号:CSB-EP006507MO-B
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规格:
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来源:E.coli
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共轭:Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他:
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货号:CSB-BP006507MO
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规格:
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来源:Baculovirus
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其他:
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货号:CSB-MP006507MO
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规格:
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来源:Mammalian cell
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其他:
产品详情
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纯度:>85% (SDS-PAGE)
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基因名:
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Uniprot No.:
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别名:DaxxDeath domain-associated protein 6; Daxx
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种属:Mus musculus (Mouse)
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蛋白长度:Full length protein
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表达区域:1-739
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氨基酸序列MATDDSIIVL DDDDEDEAAA QPGPSNLPPN PASTGPGPGL SQQATGLSEP RVDGGSSNSG SRKCYKLDNE KLFEEFLELC KTETSDHPEV VPFLHKLQQR AQSVFLASAE FCNILSRVLA RSRKRPAKIY VYINELCTVL KAHSIKKKLN LAPAASTTSE ASGPNPPTEP PSDLTNTENT ASEASRTRGS RRQIQRLEQL LALYVAEIRR LQEKELDLSE LDDPDSSYLQ EARLKRKLIR LFGRLCELKD CSSLTGRVIE QRIPYRGTRY PEVNRRIERL INKPGLDTFP DYGDVLRAVE KAATRHSLGL PRQQLQLLAQ DAFRDVGVRL QERRHLDLIY NFGCHLTDDY RPGVDPALSD PTLARRLREN RTLAMNRLDE VISKYAMMQD KTEEGERQKR RARLLGTAPQ PSDPPQASSE SGEGPSGMAS QECPTTSKAE TDDDDDDDDD DDEDNEESEE EEEEEEEEKE ATEDEDEDLE QLQEDQGGDE EEEGGDNEGN ESPTSPSDFF HRRNSEPAEG LRTPEGQQKR GLTETPASPP GASLDPPSTD AESSGEQLLE PLLGDESPVS QLAELEMEAL PEERDISSPR KKSEDSLPTI LENGAAVVTS TSVNGRVSSH TWRDASPPSK RFRKEKKQLG SGLLGNSYIK EPMAQQDSGQ NTSVQPMPSP PLASVASVAD SSTRVDSPSH ELVTSSLCSP SPSLLLQTPQ AQSLRQCIYK TSVATQCDPE EIIVLSDSD
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蛋白标签:Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
产品提供形式:Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
复溶:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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储存条件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保质期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
货期:Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事项:Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet :Please contact us to get it.
靶点详情
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功能:Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1...显示更多
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基因功能参考文献:
- DAXX can induce ovarian cancer ascites formation by activating the ERK signal pathway and binding to CEBP-beta. PMID: 30336783
- PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX and DAXX. PMID: 28341773
- data support a model in which activation of myogenic differentiation results in PML NB loss, chromatin reorganization and DAXX relocalization, and provides a paradigm for understanding the consequence of PML loss in other cellular contexts, such as during cancer development and progression PMID: 28358373
- This study provides important details regarding the expression and post-translational modifications of DAXX in aging in the entire organism and provides reference data for the deregulation observed in age-associated diseases. PMID: 27465500
- Daxx and Atrx safeguard the genome by silencing repetitive elements when DNA methylation levels are low. PMID: 26340527
- The protein levels of Daxx is reduced in Stella-null oocytes and embryos. PMID: 26325466
- Daxx selectively represses IL-6 transcription through HDAC1-mediated histone deacetylation PMID: 24550390
- Overall, these data imply a regulatory role for Daxx in reovirus-induced apoptosis, depending on its location in the nucleus or cytoplasm. PMID: 23302889
- phosphorylation of Daxx by RIP3 comprises an important part of ischemic necrosis in rat retinal ganglion cells PMID: 23260419
- DAXX is associated with regulatory regions of selected activity-regulated genes, where it promotes H3.3 loading upon membrane depolarization. DAXX loss not only affects H3.3 deposition but also impairs transcriptional induction of these genes. PMID: 22500635
- Neither Daxx nor PML, the main players of ND10-based immunity, are required for the block to viral gene expression in the S/G2 phase. PMID: 21832009
- HIRA interacts with H3.3/H4 in the absence of Daxx. PMID: 21047901
- Both Daxx and macrophage Ste20-like kinase (MST)1 are key mediators of microglial cell death induced by the proinflammatory cytokine interferon (IFN)-gamma. PMID: 21572393
- Characterizing the N- and C-terminal Small ubiquitin-like modifier (SUMO)-interacting motifs of the scaffold protein DAXX. PMID: 21383010
- Using the transcriptional coregulator Daxx as a model, we show that SUMO paralog-selective binding and conjugation are regulated by phosphorylation of the Daxx SUMO-interacting motif (SIM). PMID: 21474068
- suppresses gp130-mediated cell growth and survival by two independent mechanisms: inhibition of STAT3-induced transcription and down-regulation of Bcl2 expression PMID: 21108476
- Daxx functions as an H3.3-specific chaperone and facilitates the deposition of H3.3 at heterochromatin loci in the context of the ATRX-Daxx complex PMID: 20651253
- Overexpressed WT human DJ-1 prevents Daxx translocation and abolishes cytotoxicity in mouse Neuro-2a cells. PMID: 20014998
- The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx PMID: 11842083
- Daxx-mediated accumulation of human cytomegalovirus tegument protein pp71 at ND10 facilitates initiation of viral infection at these nuclear domains PMID: 12097584
- IFN-alpha-induced up-regulation and nuclear translocation of Daxx are completely abrogated in the absence of tyk2. PMID: 12391177
- HIPK1 and Daxx collaborate in regulating transcription. PMID: 12529400
- role in enhancing Fas-mediated apoptosis in a murine pro-B cell line, BAF3 PMID: 12681512
- Limitin suppresses B-cell growth through activation of Tyk2, resulting in the up-regulation and nuclear translocation of Daxx PMID: 14662340
- Study provides the novel molecular link between Daxx and DNMT1, which establishes a repressive transcription complex in the cell nucleus. PMID: 14978102
- Daxx and SWI/SNF protein ATRX are regulated by heterochromatin and ND10 during the cell cycle PMID: 15252119
- Mouse T cell lymphoma cells transfected with mutant genes were resistant to apoptosis induced by the anti-Fas antibody, indicating that the missense mutations found in MF were loss-of-function mutations. PMID: 15539917
- Mutant SOD1 mice show increased numbers of positive motoneurons and Daxx nuclear bodies weeks before onset of lateral sclerosis. PMID: 16581901
- Interferon-induced growth suppression of B lymphocytes requires nuclear localization of Daxx through its sumoylation and proper interactions with promyelocytic leukemia protein (PML). PMID: 16818774
- These results provide mechanistic insights into Daxx in SUMO-dependent transcriptional control and subnuclear compartmentalization. PMID: 17081986
- Potential function of Daxx as a c-met repressor during cancer progression. PMID: 17952115
- Daxx participates in myocardial ischemia/reperfusion proapoptotic signaling in vivo. PMID: 18025529
- Daxx recruits DNA methyl transferase 1 (Dnmt1) to target promoters, resulting in synergistic repression. PMID: 18413714
- role in the early apoptotic response to ischemic renal injury PMID: 18480747
- Daxx and GLUT4 interact with JNK1 through D-sites in their NH(2)-(aa 1-501) and large endofacial loop, respectively. Daxx interacts with kinesin KIF5B through the 6xTPR domain of the kinesin light chain. PMID: 18932217
- Daxx overexpression protected the cells from apoptosis, while they were sensitised to cell death following its down-regulation by siRNA. PMID: 19017466
- These studies implicate CHIP as a stress-dependent regulator of Daxx that counters the pro-apoptotic influence of Daxx in the cell. PMID: 19465479
收起更多
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亚细胞定位:Cytoplasm. Nucleus, nucleoplasm. Nucleus, PML body. Nucleus, nucleolus. Chromosome, centromere.
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蛋白家族:DAXX family
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数据库链接:
KEGG: mmu:13163
STRING: 10090.ENSMUSP00000078390
UniGene: Mm.271809