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  4. Recombinant Mouse Dual specificity protein phosphatase 14 (Dusp14)

Recombinant Mouse Dual specificity protein phosphatase 14 (Dusp14)

  • 中文名称：
    小鼠Dusp14重组蛋白
  • 货号：
    CSB-YP884952MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Dusp14重组蛋白
  • 货号：
    CSB-EP884952MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Dusp14重组蛋白
  • 货号：
    CSB-EP884952MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Dusp14重组蛋白
  • 货号：
    CSB-BP884952MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Dusp14重组蛋白
  • 货号：
    CSB-MP884952MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dusp14
  • Uniprot No.：
  • 别名：
    Dusp14; Mkp6Dual specificity protein phosphatase 14; EC 3.1.3.16; EC 3.1.3.48; Mitogen-activated protein kinase phosphatase 6; MAP kinase phosphatase 6; MKP-6
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-198
  • 氨基酸序列
    MSSRGHSTLP RTLMAPRMIS EGDIGGIAQI TSSLFLGRAS VASNWHLLQA RGITCVINAT IEIPNFNWPQ FEYVKVPLAD IPHAPIRLYF DTVADKIHSV SKKHGATLVH CAAGVSRSAT LCIAYLMKFH NLCLLEAYNW VKARRPVIRP NLGFWRQLID YESQLFGKSS VKMVQTPYGI IPDVYEKESR HLMPYWGI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.
  • 基因功能参考文献：
    1. Hepatocyte DUSP14 is required for maintaining hepatic metabolic homeostasis and for suppressing inflammation, a novel function that relies on constraining TAK1 hyperactivation PMID: 29077210
    2. DUSP14-knockdown in primary cardiomyocytes using its specific siRNA sequence elevated hypoxia and reoxygenation-induced activation of NF-kappaB and MAPKs signaling pathways, and reactive oxygen species generation. PMID: 29660332
    3. protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction possibly through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway PMID: 26891723
    4. DUSP14 negatively regulates TCR signaling and immune responses by inhibiting TAB1 activation. PMID: 24403530
    5. dual specificity phosphatases (Dusps) 6 and 14 are up-regulated by activation of beta-catenin in murine liver cells PMID: 23089536
    6. knockdown of CREMalpha or DUSP14 or expression of a dominant-negative form of DUSP14 increased beta-cell line proliferation and enhanced the GLP-1-induced proliferation of primary beta-cells PMID: 18025410

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  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
  • 数据库链接：

    KEGG: mmu:56405

    STRING: 10090.ENSMUSP00000018792

    UniGene: Mm.240885